caa a22 4500 477118925 CHVBK 20180405111630.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00227543 doi (NATIONALLICENCE)springer-10.1007/BF00227543 Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats [Elektronische Daten] [Duncan Mak, Siu Ip, Pui Li, Michel Poon, Kam Ko] Changes in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats for a period of 15 weeks were examined. Total glutathione level was significantly increased in kidney tissue, but were slightly decreased and increased in liver and heart tissues, respectively. The small changes in total glutathione level in the liver and heart, though not statistically significant, were associated with reciprocal alterations in the activity Of γ-glutamylcysteine synthetase (GCS). While the GCS activity was not changed in kidney tissue, the activity of γ-glutathione peroxidase was significantly increased in kidney tissue. Insulin treatment could completely or partly normalize almost all of these changes induced by diabetes. However, the decrease in hepatic glutathione S-transferases activity in diabetic rats was not reversed by the insulin treatment. The ensemble of results suggests that the diabetes-induced alterations in tissue glutathione antioxidant system may possibly reflect an inter-organ antioxidant response to a generalized increase in tissue oxidative stress associated with diabetes. Kluwer Academic Publishers, 1996 streptozotocin diabetes nationallicence oxidative stress nationallicence glutathione nationallicence glutathione antioxidant enzymes nationallicence AGES : advanced glycosylation end-products nationallicence EDTA : ethylenediamine tetraacetic acid nationallicence GCS : γ-glutamylcysteine synthetase nationallicence GlyHb : glycated hemoglobin nationallicence GPX : Se-glutathione peroxidase nationallicence GRD : glutathione reductase nationallicence GSH : reduced glutathione nationallicence GSSG : oxidized glutathione nationallicence GST : glutathione S-transferases nationallicence SSA : sulfosalicylic acid nationallicence STZ : streptozotocin nationallicence Mak Duncan Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Ip Siu Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Li Pui Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Poon Michel Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Ko Kam Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 162/2(1996-09-01), 153-158 0300-8177 162:2<153 1996 162 11010 https://doi.org/10.1007/BF00227543 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227543 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mak Duncan Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Ip Siu Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Li Pui Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Poon Michel Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Ko Kam Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 162/2(1996-09-01), 153-158 0300-8177 162:2<153 1996 162 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer