caa a22 4500 477119069 CHVBK 20180405111630.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00226066 doi (NATIONALLICENCE)springer-10.1007/BF00226066 Evidence and nature of a novel thiol-oxidase in human platelets [Elektronische Daten] [D. Kaul, V. Dhawan, M. Kaur] The study, addressed to understand whether or not human platelets possess a unique thiol-oxidase whose activity could be modulated by signalling pathway initiated upon the activation of Receptor-‘C'k revealed the existence of disulphide-dependent oxidation within these cells and this phenomenon was regulated by Receptor-‘C'k-dependent generation of second messengers especially phosphatidic acid (PA); cAMP and cGMP. Purification of this activity revealed the existence of 47 kDa protein having thiol-oxidase activity. Keeping in view these results we propose that the existence of this novel 47 kDa Thiol-oxidase within human platelets may provide a ‘crucial switch' for the regulation of Receptor-‘C'k-dependent mevalonate pathway in human platelets. Kluwer Academic Publishers, 1996 cholesterol nationallicence Receptor-‘C'k nationallicence thiol-oxidase nationallicence platelets nationallicence Kaul D. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Dhawan V. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Kaur M. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/1(1996-06-01), 81-84 0300-8177 159:1<81 1996 159 11010 https://doi.org/10.1007/BF00226066 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00226066 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaul D. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Dhawan V. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Kaur M. Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/1(1996-06-01), 81-84 0300-8177 159:1<81 1996 159 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer