caa a22 4500 477119077 CHVBK 20180405111630.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00420910 doi (NATIONALLICENCE)springer-10.1007/BF00420910 Protective role of curcumin against isoproterenol induced myocardial infarction in rats [Elektronische Daten] [Chandrasekar Nirmala, Rengarajulu Puvanakrishnan] The effect of curcumin on the biochemical changes induced by isoproterenol (ISO) administration in rats was examined. ISO (300 mg Kg−1 administered subcutaneously twice at an interval of 24 h) caused a decrease in body weight and an increase in heart weight, water content as well as in the levels of serum marker enzymes viz creatine kinase (CK), lactate dehydrogenase (LDH) and LDH1 isozyme. It also produced electrocardiographic changes such as increased heart rate, reduced R amplitude and ST elevation. Curcumin at a concentration of 200 mg.Kg−1 when administered orally, showed a decrease in serum enzyme levels and the electrocardiographic changes got restored towards normalcy. Myocardial infarction was accompanied by the disintegration of membrane polyunsaturated fatty acids expressed by increase of thiobarbituric acid reactive substance (TBARS), a measure of lipid peroxides and by the impairment of natural scavenging, characterized by the decrease in the levels of superoxide dismutase, catalase, glutathione peroxidase, ceruloplasmin, alpha tocopherol, reduced glutathione (GSH) and ascorbic acid. The oral pretreatment with curcumin two days before and during ISO administration decreased the effect of lipid peroxidation. It was shown to have a membrane stabilizing action by inhibiting the release of β-glucuronidase from nuclei, mitochondria, lysosome and microsome. Curcumin pre- and co-treatment decreased the severity of pathological changes and thus, could have a protective effect against the damage caused by myocardial infarction (MI). Kluwer Academic Publishers, 1996 isoproterenol nationallicence curcumin nationallicence myocardial infarction nationallicence antioxidant enzymes nationallicence β-glucuronidase nationallicence Nirmala Chandrasekar Department of Biotechnology, Central Leather Research Institute, 600 020, Madras, India aut Puvanakrishnan Rengarajulu Department of Biotechnology, Central Leather Research Institute, 600 020, Madras, India aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/2(1996-09-01), 85-93 0300-8177 159:2<85 1996 159 11010 https://doi.org/10.1007/BF00420910 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00420910 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nirmala Chandrasekar Department of Biotechnology, Central Leather Research Institute, 600 020, Madras, India aut NATIONALLICENCE 700 1- Puvanakrishnan Rengarajulu Department of Biotechnology, Central Leather Research Institute, 600 020, Madras, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/2(1996-09-01), 85-93 0300-8177 159:2<85 1996 159 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer