caa a22 4500 477119085 CHVBK 20180405111630.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00420917 doi (NATIONALLICENCE)springer-10.1007/BF00420917 Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice [Elektronische Daten] [Robert Fontaine, Ruanna Gossett, Friedhelm Schroeder, Barbara O'Toole, Thomas Doetschman, Ann Kier] The effect of transforming growth factor beta-1 (TGFβ1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFβ1-deficient mice. Homozygous TGFβ1-deficient 129 × CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGFβ1-deficient/immunodeficient C3H mice on a SLID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (1-FABP) which decreased 3-fold in the TGFβ1-deficient/immunodeficient C3H mice only. Thus, TGFβ1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively. Kluwer Academic Publishers, 1996 fatty acid binding protein nationallicence liver nationallicence intestine nationallicence growth factor nationallicence TGFβ1 nationallicence L-FABP : liver fatty acid binding protein nationallicence I-FABP : intestinal fatty acid binding protein nationallicence TGFβ1 : transforming growth factor beta-1 nationallicence TNF-α : tumor necrosis factor-α nationallicence MIP-α : macrophage inflammatory protein-α nationallicence PMSF : phenylmethyl sulfonyl fluoride nationallicence PBS : phosphate buffered saline nationallicence Fontaine Robert Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut Gossett Ruanna Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut Schroeder Friedhelm Department of Veterinary Physiology and Pharmacology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut O'Toole Barbara Division of Comparative Pathology, Department of Pathology, University of Cincinnati Medical Center, 45267-0529, Cincinnati, OH, USA aut Doetschman Thomas Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, 45267-0529, Cincinnati, OH, USA aut Kier Ann Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/2(1996-09-01), 149-153 0300-8177 159:2<149 1996 159 11010 https://doi.org/10.1007/BF00420917 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00420917 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fontaine Robert Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut NATIONALLICENCE 700 1- Gossett Ruanna Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut NATIONALLICENCE 700 1- Schroeder Friedhelm Department of Veterinary Physiology and Pharmacology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut NATIONALLICENCE 700 1- O'Toole Barbara Division of Comparative Pathology, Department of Pathology, University of Cincinnati Medical Center, 45267-0529, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Doetschman Thomas Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, 45267-0529, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Kier Ann Department of Veterinary Pathobiology, Texas A & M University, TVMC, 77843-4467, College Station, TX aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 159/2(1996-09-01), 149-153 0300-8177 159:2<149 1996 159 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer