caa a22 4500 477119255 CHVBK 20180405111631.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF00225839 doi (NATIONALLICENCE)springer-10.1007/BF00225839 Relationship between membrane potential and respiration rate in isolated liver mitochondria from rats fed an energy dense diet [Elektronische Daten] [Lilla ionetti, Susanna Iossa, Martin Brand, Giovanna Liverini] We studied the relationship between membrane potential and respiration rate in isolated liver mitochondria from rats fed an energy dense diet. We conceptually divided the system into blocks of reactions that produced or consumed mitochondrial membrane potential and then measured the kinetic response of these blocks of reactions to this potential using NAD-linked and FAD-linked substrates. We show that decreased respiration rate with an NAD-linked substrate is accounted for by decreased kinetic response of the substrate oxidation pathway to the potential. No variation in the kinetic response of the above blocks of reactions to the potential was found using an FAD-linked substrate. These results indicate that FAD-linked and NAD-linked pathways are differently affected in rats fed an energy dense diet. Kluwer Academic Publishers, 1996 mitochondria nationallicence oxygen consumption nationallicence top-down elasticity analysis nationallicence energy dense diet nationallicence ionetti Lilla Department of General and Environmental Physiology, University of Naples, Naples, Italy aut Iossa Susanna Department of General and Environmental Physiology, University of Naples, Naples, Italy aut Brand Martin Department of Biochemistry, University of Cambridge, Tennis Court Road, CB2 1QW, Cambridge, England aut Liverini Giovanna Department of General and Environmental Physiology, University of Naples, Naples, Italy aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 158/2(1996-05-01), 133-138 0300-8177 158:2<133 1996 158 11010 https://doi.org/10.1007/BF00225839 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00225839 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- ionetti Lilla Department of General and Environmental Physiology, University of Naples, Naples, Italy aut NATIONALLICENCE 700 1- Iossa Susanna Department of General and Environmental Physiology, University of Naples, Naples, Italy aut NATIONALLICENCE 700 1- Brand Martin Department of Biochemistry, University of Cambridge, Tennis Court Road, CB2 1QW, Cambridge, England aut NATIONALLICENCE 700 1- Liverini Giovanna Department of General and Environmental Physiology, University of Naples, Naples, Italy aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 158/2(1996-05-01), 133-138 0300-8177 158:2<133 1996 158 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer