caa a22 4500 477119360 CHVBK 20180405111631.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240039 doi (NATIONALLICENCE)springer-10.1007/BF00240039 The endogenous digitalis-like factor [Elektronische Daten] [František Kölbel, Vratislav Schreiber] Intensive search into the presence of endogenous digitalis-like factor (EDLF) started shortly after identification of the alpha subunit of the Na,K,-ATPase as being receptor for digitalis glycosides. After years of skepticism, present data testify EDLF really exists. Most probably, the EDLF has chemical structure of either ouabain or of one of its isomers. It is secreted by the adrenal cortex, and, under conditions of stress, it's secretion is regulated differently from the secretion of both gluco- and mineralocorticoids. The physiological role of the EDLF has not been fully understood yet. In the newborn's kidneys, the inhibition of the Na,K-ATPase may assist to increase elimination of surplus sodum from the organism. In individuals of any age, the inhibitory influence of EDLF upon Na,K-ATPase in the arterial wall smooth muscle cells increases peripheral vascular resistance and thus, blood pressure. In the tissue culture, direct positive inotropic influences of EDLF upon rat cardiomyocytes was observed. However, the importance of positive inotropic effect of the EDLF upon the heart in clinical medicine remains to be elucidated. (Mol Cell Biochem 160/161: 111-115, 1996) Kluwer Academic Publishers, 1996 digitalis-like factor nationallicence ouabain nationallicence Na,K-ATPase nationallicence adrenal cortex nationallicence Kölbel František 1st Department of Medicine, Charles University 2nd School of Medicine, Charles University 2nd School of Medicine, Prague, Czech Republic aut Schreiber Vratislav Laboratory for Endocrinology and Metabolism, 3rd Department of Medicine, Charles University 1st School of Medicine, Prague, Czech Republic aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 111-115 0300-8177 160-161:1<111 1996 160-161 11010 https://doi.org/10.1007/BF00240039 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240039 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kölbel František 1st Department of Medicine, Charles University 2nd School of Medicine, Charles University 2nd School of Medicine, Prague, Czech Republic aut NATIONALLICENCE 700 1- Schreiber Vratislav Laboratory for Endocrinology and Metabolism, 3rd Department of Medicine, Charles University 1st School of Medicine, Prague, Czech Republic aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 111-115 0300-8177 160-161:1<111 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer