caa a22 4500 477119409 CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240063 doi (NATIONALLICENCE)springer-10.1007/BF00240063 Myocardial infarction and nitric oxide [Elektronische Daten] [Richard Bing, Hiroshi Suzuki] The report deals with the induction of the inducible form of nitric oxide synthase (iNOS) in infarcted heart muscle of rabbit and man. In the rabbit, nitric oxide synthase was significantly increased in the infarcted area beginning on the third day following ligation of a coronary artery. iNOS induction occured primarily in macrophages. In man, iNOS immunoreactivity was also primarily localized in macrophages on the seventh day following death from myocardial infarction. Of the specific inhibitors of iNOS in infarcted heart muscle, S-methylisothiourea (SMT) was the most potent. Its greatest effect occured in the normal non-affected area of the heart. Dexamethasone and cyclosporin A failed to inhibit NOS. Apoptosis of macrophages commenced two days following ligation of a coronary artery. Kluwer Academic Publishers, 1996 infarcted heart nationallicence myocardial infarction nationallicence nitric oxide synthase nationallicence apoptosis nationallicence Bing Richard Department of Experimental Cardiology, Huntington Medical Research Institutes, 99 N. El Molino Avenue, 91101, Pasadena, CA, USA aut Suzuki Hiroshi Department of Experimental Cardiology, Huntington Medical Research Institutes, 99 N. El Molino Avenue, 91101, Pasadena, CA, USA aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 303-306 0300-8177 160-161:1<303 1996 160-161 11010 https://doi.org/10.1007/BF00240063 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240063 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bing Richard Department of Experimental Cardiology, Huntington Medical Research Institutes, 99 N. El Molino Avenue, 91101, Pasadena, CA, USA aut NATIONALLICENCE 700 1- Suzuki Hiroshi Department of Experimental Cardiology, Huntington Medical Research Institutes, 99 N. El Molino Avenue, 91101, Pasadena, CA, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 303-306 0300-8177 160-161:1<303 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer