caa a22 4500 47711945X CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240043 doi (NATIONALLICENCE)springer-10.1007/BF00240043 Reversible and irreversible damage in reoxygenated ‘ischemic' ventricular myocytes in culture [Elektronische Daten] [Arié Pinson, Régine Tirosh] The LDH release pattern from cardiomyocytes under ‘ischemia-like' conditions shows two phases. In the initial slow phase, reoxygenation immediately stops further enzyme release. Accelerated LDH release, which occurs concomitantly with Iysosomal enzyme release, characterizes the second phase of ‘ischemia.' Reoxygenation at this stage does not put a stop to further enzyme release. Reoxygenation during the first phase of ‘ischemia' rapidly restored ATP level, while in the second phase, ATP levels remained low even after 6 h of reoxygenation. This study as well as previous data seem to suggest that irreversible cellular damage leading to cell death, occurs by synergistic action of many effectors, each of which does not necessarily cause irreversible damage. KluwerAcademic Publishers, 1996 cardiomyocytes nationallicence ischemia nationallicence heart nationallicence reoxygenation nationallicence ATP nationallicence LDH nationallicence hexosaminidase nationallicence Pinson Arié Laboratory for Myocardial Research, The Hebrew University - Hadassah Medical School, Jerusalem, Israel aut Tirosh Régine Laboratory for Myocardial Research, The Hebrew University - Hadassah Medical School, Jerusalem, Israel aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 137-141 0300-8177 160-161:1<137 1996 160-161 11010 https://doi.org/10.1007/BF00240043 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240043 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pinson Arié Laboratory for Myocardial Research, The Hebrew University - Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 700 1- Tirosh Régine Laboratory for Myocardial Research, The Hebrew University - Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 137-141 0300-8177 160-161:1<137 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer