caa a22 4500 477119484 CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240051 doi (NATIONALLICENCE)springer-10.1007/BF00240051 Salvage of jeopardized myocardium by ischemic preconditioning: Is the quest over? [Elektronische Daten] [Rudolf Strasser, Patrik Htun, Wolfgang Schaper] Helmholtz is quoted to have said that if he'd had any influence in creation he would have returned the human eye to its maker for revisions. The same could be said of the heart with its only very rudimentary ability to defend itself against ischemia. Ischemia was obviously not a problem during evolution: Early man did not live much longer than prime time for reproduction and no selection bias existed to prevent vascular diseases, an affliction of later life. In spite of this natural disadvantage of aged males the number of existing although not very efficient defense mechanisms is surprisingly large. It is the general belief that the knowledge of these mechanisms may lead to the development of new therapies that hopefully improve the imperfect product of natural selection. (Mol Cell Biochem 160/161: 209-215, 1996) Kluwer Academic Publishers, 1996 myocardial ischemia nationallicence stunned myocardium nationallicence preconditioning nationallicence angiogenic response nationallicence Strasser Rudolf Max-Planck-Institute for Physiological and Clinical Research, Kerckhoff-Klinik, Benekestrasse 4-8, 61231, Bad Nauheim, Germany aut Htun Patrik Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Benekestrasse 2, D-61231, Bad Nauheim, Germany aut Schaper Wolfgang Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Benekestrasse 2, D-61231, Bad Nauheim, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 209-215 0300-8177 160-161:1<209 1996 160-161 11010 https://doi.org/10.1007/BF00240051 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240051 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Strasser Rudolf Max-Planck-Institute for Physiological and Clinical Research, Kerckhoff-Klinik, Benekestrasse 4-8, 61231, Bad Nauheim, Germany aut NATIONALLICENCE 700 1- Htun Patrik Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Benekestrasse 2, D-61231, Bad Nauheim, Germany aut NATIONALLICENCE 700 1- Schaper Wolfgang Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Benekestrasse 2, D-61231, Bad Nauheim, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 209-215 0300-8177 160-161:1<209 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer