caa a22 4500 477119492 CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240025 doi (NATIONALLICENCE)springer-10.1007/BF00240025 Control of cardiac performance by Ca-turnover [Elektronische Daten] [Jiří Šimurda, Milena Šimurdová, Pavel Bravený, Georges Christé] A quantitative model of Ca-turnover in cardiac cells that incorporates negative feedback modulation of sarcolemmal calcium transport (via Ca channels and Na/Ca exchange) has been designed. The Na/Ca exchange current was expressed as INaCa = I NaCar + Δ Naca . The component I NaCar reflects slow changes of Ca2+ and Na+ concentrations and depends on the Na/K pump. ΔI NaCa is the fast component related to the Ca2+ transient. The single input to the model is an arbitrary sequence of intervals between excitations; outputs are sequences of calcium amounts transferred among the compartments during individual intervals. The model operates with a combination of discrete variables (amounts of Ca transferred during contraction, relaxation and rest) and continuous variables — slow changes in ionic concentrations. Since the model is not formalistic but respects the nature of the underlying elements of the system, it enables us to simulate the known effects of cardiotropic drugs or to predict their unknown mechanisms by visualizing the changes in individual Ca compartments. By altering the parameters, the model also simulates the known species and tissue differences in rate-dependent phenomena. Kluwer Academic Publishers, 1996 excitation-contraction coupling nationallicence sodium-calcium exchange nationallicence calcium current nationallicence mammalian heart muscle nationallicence rate dependency nationallicence quantitative model nationallicence Šimurda Jiří INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut Šimurdová Milena INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut Bravený Pavel INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut Christé Georges INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 5-12 0300-8177 160-161:1<5 1996 160-161 11010 https://doi.org/10.1007/BF00240025 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240025 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Šimurda Jiří INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut NATIONALLICENCE 700 1- Šimurdová Milena INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut NATIONALLICENCE 700 1- Bravený Pavel INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut NATIONALLICENCE 700 1- Christé Georges INSERM U 121, 18 Ave Doyen, Lépine, F-69500, Bron, France aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 5-12 0300-8177 160-161:1<5 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer