caa a22 4500 477119581 CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240046 doi (NATIONALLICENCE)springer-10.1007/BF00240046 Role of reactive oxygen species in cardiovascular aging [Elektronische Daten] [Claudio Muscari, Antonella Giaccari, Emanuele Giordano, Carlo Clô, Carlo Guarnieri, Claudio Caldarera] Biochemical and structural changes occurring in the myocardium with aging are mainly resulting from the association of a general tissue atrophy with the hypertrophy of the remaining myocytes. Whilst hypertrophy seems to be a compensatory process to the loss of cardiomyocytes and to a mild systolic hypertensive condition that accompanies elderly people, atrophy should be the modification more closely related to aging ‘per se.' In support to the free radical theory of aging, several signs of oxidative damage have been shown in the aged heart, such as lipofuscin accumulation, decreased phospholipid unsaturation index, greater formation of both hydrogen peroxide and 8-hydroxy-2′deoxyguanosine. As a compensatory reaction, the activities of the main oxygen-radical scavenger enzymes are stimulated in the mitochondria of aged rat heart. Endothelium-mediated vasoregulation is more susceptible to oxidative stress in aged with respect to young rats, suggesting that also the vasculature can be negatively influenced by the oxygen free radicals generated during aging. The possible primary role of oxygen free radicals in the development of myocardial atrophy is also discussed. Kluwer Academic Publishers, 1996 reactive oxygen species nationallicence 8-hydroxy-2′-deoxyguanosine nationallicence heart nationallicence nitric oxide nationallicence aging nationallicence rat nationallicence Muscari Claudio Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Giaccari Antonella Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Giordano Emanuele Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Clô Carlo Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Guarnieri Carlo Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Caldarera Claudio Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 159-166 0300-8177 160-161:1<159 1996 160-161 11010 https://doi.org/10.1007/BF00240046 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240046 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muscari Claudio Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Giaccari Antonella Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Giordano Emanuele Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Clô Carlo Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Guarnieri Carlo Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Caldarera Claudio Center of Research on Heart Metabolism, Department of Biochemistry ‘G. Moruzzi', University of Bologna, Bologna, Italy aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 159-166 0300-8177 160-161:1<159 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer