caa a22 4500 477119611 CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240061 doi (NATIONALLICENCE)springer-10.1007/BF00240061 Glycogen phosphorylase isoenzyme BB in diagnosis of myocardial ischaemic injury and infarction [Elektronische Daten] [Ernst-Georg Krause, Georg Rabitzsch, Franz Noll, Johannes Maire, Bernd Puschendorf] This review deals with glycogen phosphorylase (GP) and its isoenzyme BB in the diagnosis of ischaemic myocardial injury. Early identification and confirmation of acute myocardial infarction is essential for correct patient care and disposition decision in the emergency department. In this respect, glycogen phosphorylase isoenzyme BB (GPBB) based on its metabolic function is an enzyme for early laboratory detection of ischaemia. In the aerobic heart muscle GPBB together with glycogen is tightly associated with the vesicles of the sarcoplasmic reticulum. Release of GPBB, the main isoform in the human myocardium, essentially depends on the degradation of glycogen, which is catalyzed by GP. Ischaemia is known to favour the conversion of bound GP in the b form into GP a, thereby accelerating glycogen breakdown, which is the ultimate prerequisite for getting GP into a soluble form being able to move freely in the cytosol. The efflux of GPBB into the extracellular fluid follows if ischaemia-induced structural alterations in the cell membrane become manifest. The clinical application of GPBB as a marker of ischaemic myocardial injury is a very promising tool for extending our knowledge of the severity of myocardial ischaemic events in the various coronary syndromes. The rational roots of this development were originated from Albert Wollenberger's research work on the biochemistry of cardiac ischaemia and the transient acceleration of glycogenolysis mainly brought about by GP activation. KluwerAcademic Publishers, 1996 myocardial infarction nationallicence glycogen phosphorylase nationallicence isoenzyme BB nationallicence glycogenolysis nationallicence enzyme release nationallicence glycogen-glycogenolysis-complex nationallicence cardiac ischaemia nationallicence Krause Ernst-Georg Max Delbrück Center for Molecular Medicine, Department of Molecular Cardiology, Berlin-Buch, Germany aut Rabitzsch Georg Max Delbrück Center for Molecular Medicine, Department of Molecular Cardiology, Berlin-Buch, Germany aut Noll Franz Institute of Medical Diagnostics, Berlin-Steglitz, Germany aut Maire Johannes Department of Medical Chemistry and Biochemistry, University Innsbruck, Innsbruck, Austria aut Puschendorf Bernd Department of Medical Chemistry and Biochemistry, University Innsbruck, Innsbruck, Austria aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 289-295 0300-8177 160-161:1<289 1996 160-161 11010 https://doi.org/10.1007/BF00240061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krause Ernst-Georg Max Delbrück Center for Molecular Medicine, Department of Molecular Cardiology, Berlin-Buch, Germany aut NATIONALLICENCE 700 1- Rabitzsch Georg Max Delbrück Center for Molecular Medicine, Department of Molecular Cardiology, Berlin-Buch, Germany aut NATIONALLICENCE 700 1- Noll Franz Institute of Medical Diagnostics, Berlin-Steglitz, Germany aut NATIONALLICENCE 700 1- Maire Johannes Department of Medical Chemistry and Biochemistry, University Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 700 1- Puschendorf Bernd Department of Medical Chemistry and Biochemistry, University Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 289-295 0300-8177 160-161:1<289 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer