caa a22 4500 47711962X CHVBK 20180405111632.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240064 doi (NATIONALLICENCE)springer-10.1007/BF00240064 Estrogen effects in the heart [Elektronische Daten] [T. Pelzer, A. Shamim, L. Neyses] Gender specific differences in cardiovascular disease are largely mediated by sex hormones. The use of estrogens significantly reduces the overall incidence of heart disease in postmenopausal women. Beneficial effects of estrogens on plasma lipoprotein levels are clearly established. However, these do not explain the magnitude of risk reduction seen in clinical studies. Thus, additional and currently unknown functions of estrogens must be operative. Elucidation of the exact estrogen action in the heart will have important implications in the treatment of cardiovascular disease. It will probably enhance the therapeutic repertoire in treating heart disease, the most common cause of death in industrialized countries. We will review the current understanding of the function of estrogens in the heart and discuss potential strategies on how to apply these data to clinical practice. Kluwer Academic Publishers, 1996 myocardium nationallicence hypertension nationallicence gene expression nationallicence estrogens nationallicence cardiac hypertrophy nationallicence signal transduction nationallicence genetic program nationallicence Pelzer T. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut Shamim A. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut Neyses L. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 307-313 0300-8177 160-161:1<307 1996 160-161 11010 https://doi.org/10.1007/BF00240064 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240064 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pelzer T. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut NATIONALLICENCE 700 1- Shamim A. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut NATIONALLICENCE 700 1- Neyses L. Department of Medicine, University of Würzburg, Joseph-Schneider Strasse 2, D-97080, Würzburg, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 307-313 0300-8177 160-161:1<307 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer