caa a22 4500 477119743 CHVBK 20180405111633.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00240056 doi (NATIONALLICENCE)springer-10.1007/BF00240056 Protaglandins and the antiarrhythmic effect of preconditioning in the isolated rat heart [Elektronische Daten] [Michael Arad, Tatiana Oxman, Ron Leor, Babeth Rabinowitz] Our study evaluated the relationship between the endogenous production of prostacyclin and the antiarrhythmic effect of ischemic preconditioning against ischemic and reperfusion-induced tachyarrhythmia. Langendorff perfused rat hearts underwent 30 min regional ischemia with reperfusion. Preconditioning was induced by a single episode of 5 min ischemia and 15 min reperfusion. Prostaglandin 6-keto F1α (a stable metabolite of prostacyclin) was determined in the coronary effluent. In the control group the incidence of tachyarrhythmia was 31 % during ischemia and 67% during reperfusion. Preconditioning did not affect ischemic arrhythmias but attenuated arrhythmias a reperfusion (8%, p < 0.01) and was associated with increased release of prostacyclin prior to reperfusion. Aspirin abolished the antiarrhythmic effect of preconditioning against reperfusion tachyarrhythmias. However, no relationship was found between suppression of prostacyclin production and the occurrence of arrhythmia in individual hearts. Thus, our findings suggest that metabolites of arachidonic acid via the cyclooxygenase pathway are involved in the protective effect of ischemic preconditioning against reperfusion-induced tachyarrhythmias. (Mol Cell Biochem 160/161: 249-255, 1996) Kluwer Academic Publishers, 1996 preconditioning nationallicence arrhythmia nationallicence prostacyclin nationallicence aspirin nationallicence rat nationallicence Arad Michael Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut Oxman Tatiana Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut Leor Ron Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut Rabinowitz Babeth Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 249-255 0300-8177 160-161:1<249 1996 160-161 11010 https://doi.org/10.1007/BF00240056 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00240056 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arad Michael Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Oxman Tatiana Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Leor Ron Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Rabinowitz Babeth Cardiac Metabolism Laboratory, Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 160-161/1(1996-03-01), 249-255 0300-8177 160-161:1<249 1996 160-161 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer