caa a22 4500 477119956 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227877 doi (NATIONALLICENCE)springer-10.1007/BF00227877 Signalling by cGMP-dependent protein kinases [Elektronische Daten] [Arie Vaandrager, Hugo de Jonge] The second messenger cGMP is a major intracellular mediator of the vaso-active agents nitric oxide and natriuretic peptides. The principal targets of cGMP are (i) phosphodiesterases, resulting in interference with the CAMP-signalling pathway, (ii) cGMPgated cation channels, and (iii) cGMP-dependent protein kinases (cGKs). Only two mammalian isotypes of cGK have been described so far: type I cGK, consisting of an α and a β isoform, presumably splice variants of a single gene, and identified as the most prominent cGK isotype in the cardio-vascular system; and type II cGK, expressed mainly in the intestine, the kidney and the brain. High levels of cGK I are found in vascular smooth muscle cells, endothelial cells and platelets. In these cells, cGK I is thought to counteract the increase in contraction provoked by Ca-mobilizing agonists, to reduce endothelial permeability and to inhibit platelet aggregation, respectively. Relatively low levels of cGK I are found in cardiomyocytes. In this cell type, cGK is implicated in the negative inotropic effect of cGMP, presumably through modulation of Ca channels and by diminishing the Ca-sensitivity of contractile proteins. Kluwer Academic Publishers, 1996 cyclic GMP nationallicence nitric oxide nationallicence natriuretic peptides nationallicence guanylyl cyclase nationallicence cardiomyocytes nationallicence endothelium nationallicence Vaandrager Arie Department of Biochemistry, Cardiovascular Research Institute COEUR, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands aut de Jonge Hugo Department of Biochemistry, Cardiovascular Research Institute COEUR, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 23-30 0300-8177 157:1-2<23 1996 157 11010 https://doi.org/10.1007/BF00227877 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227877 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vaandrager Arie Department of Biochemistry, Cardiovascular Research Institute COEUR, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- de Jonge Hugo Department of Biochemistry, Cardiovascular Research Institute COEUR, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 23-30 0300-8177 157:1-2<23 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer