caa a22 4500 477119964 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227908 doi (NATIONALLICENCE)springer-10.1007/BF00227908 Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease [Elektronische Daten] [G. Noll, R. Wenzel, T. Lüscher] Endothelin-1 is a recently discovered peptide mainly released from endothelial cells. Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and transforming growth factor β1 stimulate the fomation of the peptide. On the other hand the synthesis of endothelin is inhibited by nitric oxide and atrial natriuretic peptide via the formation of cyclic guanosine monophosphate. Released from endothelial cells endothelin-1 mediates transient vasodilation followed by a profound and longlasting vasoconstriction. Endothelin is also a mitogen for smooth muscle proliferation. Endothelins exert their biological effects via activation of specific receptors. Two different receptors have been cloned from mammalian tissues (ETA and ETB receptors). On vascular smooth muscle cells both receptors mediate contractions. Endothelial cells only express ETB receptors linked to the formation of nitric oxide and/or prostacyclin formation. Increased plasma concentrations of endothelin-1 have been described in a variety of diseases such as pulmonary hypertension, arteriosclerosis, renal failure, acute coronary syndromes, heart failure, migraine and vascular diseases. Recently an increasing number of endothelin receptor antagonists have been synthetized, which have been shown to inhibit endothelin-mediated vasoconstriction. Clinical studies are now ongoing to elucidate the pathophysiologic role of endothelin and the potential benefit of the blockade of the system in different disease states. Kluwer Academic Publishers, 1996 endothelium nationallicence endothelin nationallicence endothelin receptor antagonist nationallicence Noll G. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut Wenzel R. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut Lüscher T. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 259-267 0300-8177 157:1-2<259 1996 157 11010 https://doi.org/10.1007/BF00227908 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227908 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noll G. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut NATIONALLICENCE 700 1- Wenzel R. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut NATIONALLICENCE 700 1- Lüscher T. Cardiology, Cardiovascular Research University Hospital, Bern, Switzerland aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 259-267 0300-8177 157:1-2<259 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer