caa a22 4500 477120156 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227903 doi (NATIONALLICENCE)springer-10.1007/BF00227903 Inositolpolyphosphates and their binding proteins —a short review [Elektronische Daten] [Barbara Huisamen, Amanda Lochner] Since 1983, when it was discovered that inositol 1,4,5-trisphosphate can act as second messenger to release Ca2+ from the endoplasmic reticulum, widespread research has focused on the phosphatidylinositol signalling transduction pathway and the host of inositolphosphates formed intracellularly after stimulation thereof. Although the polyphosphates, inositoltetrakisphosphate (InsP4) and inositolhexakisphosphate (InsP6), have received their share of attention, a definite physiological role has not been ascribed to them as yet. Different binding proteins for these two polyphosphates have been demonstrated, especially in brain tissue, indicating their possible importance in the cell. InsP6 is known as one of nature's most powerful antioxidants and has already been demonstrated to possess the abilities to be of use in the industry as well as in the medical profession. As its natural actions are poorly understood and its possible side-effects have not been widely investigated, basic research regarding its cellular and subcellular activities is urgently called for. Kluwer Academic Publishers, 1996 InsP4 nationallicence InsP6 nationallicence binding proteins nationallicence polyphosphates nationallicence antioxidant nationallicence Huisamen Barbara Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa aut Lochner Amanda Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 229-232 0300-8177 157:1-2<229 1996 157 11010 https://doi.org/10.1007/BF00227903 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227903 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huisamen Barbara Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa aut NATIONALLICENCE 700 1- Lochner Amanda Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 229-232 0300-8177 157:1-2<229 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer