caa a22 4500 477120180 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227907 doi (NATIONALLICENCE)springer-10.1007/BF00227907 Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure [Elektronische Daten] [Wilhelm Schmitz, Peter Boknik, Bettina Linck, Frank Müller] In end-stage heart failure the expression of different myocardial regulatory proteins involved in the β-adrenergic cAMP signalling pathway is altered. The downregulation of β-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding protein seem to be the most important alterations. Since catecholamine levels are elevated in these patients and since some alterations can be ‘restored' after treatment with β-adrenoceptor antagonists it was hypothesized that excessive β-adrenergic stimulation could be involved in these alterations. In this article the changes of β-adrenergic receptors, GTP-binding proteins, sarcoplasmic reticulum Ca2+-ATPase and of phospholamban found in heart failure are addressed with its possible therapeutic implications. Kluwer Academic Publishers, 1996 heart failure nationallicence adrenergic receptor nationallicence muscarinic receptor nationallicence G-protein nationallicence phosphodiesterase inhibitor nationallicence angiotensin converting enzyme inhibitor nationallicence β-adrenoceptor antagonist nationallicence Schmitz Wilhelm Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut Boknik Peter Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut Linck Bettina Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut Müller Frank Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 251-258 0300-8177 157:1-2<251 1996 157 11010 https://doi.org/10.1007/BF00227907 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227907 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmitz Wilhelm Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut NATIONALLICENCE 700 1- Boknik Peter Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut NATIONALLICENCE 700 1- Linck Bettina Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut NATIONALLICENCE 700 1- Müller Frank Institut fur Pharmakologie and Toxikologie, Westfälische Wilhelms-Universitdt, Domagkstr. 12, 48149, Munster, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 251-258 0300-8177 157:1-2<251 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer