caa a22 4500 477120199 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227892 doi (NATIONALLICENCE)springer-10.1007/BF00227892 Paracrine functions of the coronary vascular endothelium [Elektronische Daten] [Ingrid Fleming, Johann Bauersachs, Rudi Busse] Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress exerted by the streaming blood is the physiologically most important stimulus for a continuous endothelial NO production, which counteracts neuro- and myogenic constriction. This shear stress-dependent NO release represents a highly effective local system for maintaining adequate blood flow to the myocardial tissue. At the transcriptional level endothelium-derived NO modulates the regulation of a number of genes (e.g. monocyte chemoattractant protein-1, P-selectin and vascular cell adhesion molecule-1) most probably by direct and/or indirect interaction with transcription factors. In addition to NO and PGI2, the coronary vascular endothelium is also able to release a factor which causes hyperpolarisation of the underlying smooth muscle. This so-called endothelium-derived hyperpolarising factor (EDHF) displays the characteristics of a cytochrome P450-derived arachidonic acid metabolite. However, since NO is able to attenuate production of this factor, EDHF may contribute to the regulation of vascular tone essentially in situations associated with an apparent dysfunction of the endothelium. Kluwer Academic Publishers, 1996 endothelium nationallicence nitric oxide nationallicence endothelium-derived hyperpolarising factor nationallicence feedback inhibition nationallicence intracellular pH nationallicence tyrosine kinases nationallicence tyrosine phosphatases nationallicence shear stress nationallicence monocyte chemoattractant protein-1 nationallicence Fleming Ingrid Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut Bauersachs Johann Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut Busse Rudi Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 137-145 0300-8177 157:1-2<137 1996 157 11010 https://doi.org/10.1007/BF00227892 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227892 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fleming Ingrid Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut NATIONALLICENCE 700 1- Bauersachs Johann Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut NATIONALLICENCE 700 1- Busse Rudi Zentrum der Physiologie, Klinikum der J. W. Goethe-Universitdt, Theodor-Stern-Kai 7, D-60590, Frankfurt/Main, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 137-145 0300-8177 157:1-2<137 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer