caa a22 4500 477120245 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227875 doi (NATIONALLICENCE)springer-10.1007/BF00227875 Phosphoinositide-generated messengers in cardiac signal transduction [Elektronische Daten] [Han van Heugten, Yvonne Eskildsen-Helmond, Henriette de Jonge, Karel Bezstarosti, Jos Lamers] A multitude of agonists like e.g. endothelin-I, angiotensin-II, serotonin, thrombin, histamine and vasopressin as well as α1-adrenergic and muscarinic stimulation lead to stimulation of the phosphoinositide cycle in the heart. Besides this seven membrane spanning-domain receptor-coupled stimulation of the key enzyme of the phosphoinositide cycle, phospholipase C-β, another class of hormones, growth factors, also couple to the phosphoinositide cycle, now through receptors with intrinsic tyrosine kinase activity that can phosphorylate and stimulate the phospholipase C-γ isozyme. In this review we summarize the multitude of receptor (sub)types, G-protein-subunit- and phospholipase C-isozymes that are present in the heart. Furthermore, generation of second messengers and cellular responses are described together with the (patho)physiological implications for the heart of phosphoinositide cycle activation and second messenger accumulation. Kluwer Academic Publishers, 1996 Phosphatidylinositol cycle nationallicence cardiomyocytes nationallicence receptors nationallicence G-proteins nationallicence phospholipase C nationallicence (patho)physiological implications nationallicence van Heugten Han Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut Eskildsen-Helmond Yvonne Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut de Jonge Henriette Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut Bezstarosti Karel Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut Lamers Jos Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 5-14 0300-8177 157:1-2<5 1996 157 11010 https://doi.org/10.1007/BF00227875 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227875 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Heugten Han Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Eskildsen-Helmond Yvonne Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- de Jonge Henriette Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Bezstarosti Karel Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Lamers Jos Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 5-14 0300-8177 157:1-2<5 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer