caa a22 4500 477120253 CHVBK 20180405111634.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF00227876 doi (NATIONALLICENCE)springer-10.1007/BF00227876 Angiotensin II signalling pathways in cardiac fibroblasts: Conventional versus novel mechanisms in mediating cardiac growth and function [Elektronische Daten] [David Dostal, George Booz, Kenneth Baker] Angiotensin II has been demonstrated to be involved in the regulation of cellular growth of several tissues in response to developmental, physiological, and pathophysiological processes. Angiotensin 11 has been implicated in the developmental growth of the left ventricle in the neonate and remodeling of the heart following chronic hypertension and myocardial infarction. The inhibition of DNA synthesis and collagen deposition in myocardial interstitium following myocardial infarction by angiotensin converting enzyme inhibitor, suggests that angiotensin II mediates interstitial and perivascular fibrobrosis by preventing fibroblast proliferation. In the past, little attention was focused on the identity and functional roles of cardiac fibroblasts. Recent in vitro studies utilizing cultured cardiac fibroblasts demonstrate that angiotensin II, acting via the AT1 receptor, initiates intracellular signalling pathways in common with those of peptide growth factors. Below, we describe growth-related aspects of cardiac fibroblasts with respect to angiotensin II receptors, conventional and novel signal transduction systems, secretion of extracellular matrix proteins and growth factors, and localization of renin-angiotensin system components. Kluwer Academic Publishers, 1996 Angiotensin II nationallicence cardiac fibroblasts nationallicence tyrosine kinases nationallicence protein kinase C nationallicence phospholipase C nationallicence extracellular matrix nationallicence Dostal David Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut Booz George Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut Baker Kenneth Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 15-21 0300-8177 157:1-2<15 1996 157 11010 https://doi.org/10.1007/BF00227876 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00227876 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dostal David Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut NATIONALLICENCE 700 1- Booz George Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut NATIONALLICENCE 700 1- Baker Kenneth Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, 17822-2611, Danville, PA, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 157/1-2(1996-04-01), 15-21 0300-8177 157:1-2<15 1996 157 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer