caa a22 4500 477120350 CHVBK 20180405111635.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00229747 doi (NATIONALLICENCE)springer-10.1007/BF00229747 An increase of acidic isoform of catalase in red blood cells from HIV(+) population [Elektronische Daten] [Sumio Yano, Maria Colon, Noriko Yano] A systemic oxidative stress of HIV (+) individuals has been recognized from a low glutathione level and a high level of inflammatory cytokines such as TNFα. Previously, we demonstrated that the catalase enzyme activity in HIV (+) population is significantly altered depending on the cell types; the level was significantly high in red blood cells while the enzymes in white blood cells were remarkably low (Res Commun Subs Abuse 16: 161-176, 1995). In this study, we further characterized the difference in RBC catalase molecules between HIV (+) and control population. We have found that RBC from HIV (+) population, whether they were asymptomatic or symptomatic, contained a significantly elevated catalase protein accompanied by the enzyme activities, and that the majority of the elevated protein were acidic pl of the molecules with an identical subunit mass of approximately 60 KDa. These results suggest that catalase is induced prior to and/or during erythroid differentiation lineage in HIV (+) population as a somatic defense to respond and compensate for a systemic oxidative stress and for an anemic condition. (Mol Cell Biochem 165: 77-81, 1996) Kluwer Academic Publishers, 1996 HIV-1 infection nationallicence antioxidants nationallicence catalase nationallicence oxidative stress nationallicence Yano Sumio Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut Colon Maria Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut Yano Noriko Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/1(1996-12-01), 77-81 0300-8177 165:1<77 1996 165 11010 https://doi.org/10.1007/BF00229747 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00229747 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yano Sumio Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut NATIONALLICENCE 700 1- Colon Maria Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut NATIONALLICENCE 700 1- Yano Noriko Department of Biochemistry, Ponce School of Medicine, 0731, Ponce, Puerto Rico, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/1(1996-12-01), 77-81 0300-8177 165:1<77 1996 165 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer