caa a22 4500 477120458 CHVBK 20180405111635.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00229479 doi (NATIONALLICENCE)springer-10.1007/BF00229479 Effects of Schisandrin B and α-tocopherol on lipid peroxidation, in vitro and in vivo [Elektronische Daten] [Duncan Mak, Siu-Po Ip, Pui-Chun Li, Michel Poon, Kam-Ming Ko] Effects of Schisandrin B (Sch B) and α-tocopherol (α-TOC) on ferric chloride (Fe3+) induced oxidation of erythrocyte membrane lipids in vitro and carbon tetrachloride (CCl4) induced lipid peroxidation in vivo were examined. While α-TOC could produce prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B only inhibited the peroxidation reaction. Pretreatment with α-TOC (3 mmol/kg/day × 3) did not protect against CCl4-induced lipid peroxidation and hepatocellular damage in mice, whereas Sch B pretreatment (0.3 mmol/3.0 mmol/kg/day × 3) produced a dose-dependent protective effect on the CCl4-induced hepatotoxicity. The ensemble of results suggests that the ability of Sch B to inhibit lipid peroxidation, while in the absence of pro-oxidant activity, may at least in part contribute to its hepatoprotective action. Kluwer Academic Publishers, 1996 Schisandrin B nationallicence α-tocopherol nationallicence ferric nationallicence lipid peroxidation nationallicence carbon tetrachloride nationallicence ALT : alanine aminotransferase nationallicence CCl4 : carbon tetrachloride nationallicence Fe3+ : ferric chloride nationallicence MDA : malondialdehyde nationallicence Sch B : Schisandrin B nationallicence TBA : 2-thiobarbituric acid nationallicence TBARS : thiobarbituric acid reactive substances nationallicence α-TOC : dl-α-tocopherol nationallicence Mak Duncan Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Ip Siu-Po Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Li Pui-Chun Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Poon Michel Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Ko Kam-Ming Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/2(1996-12-01), 161-165 0300-8177 165:2<161 1996 165 11010 https://doi.org/10.1007/BF00229479 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00229479 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mak Duncan Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Ip Siu-Po Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Li Pui-Chun Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Poon Michel Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 700 1- Ko Kam-Ming Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/2(1996-12-01), 161-165 0300-8177 165:2<161 1996 165 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer