caa a22 4500 477120482 CHVBK 20180405111635.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00229475 doi (NATIONALLICENCE)springer-10.1007/BF00229475 The relationship between altered membrane composition, eicosanoids and TNF-induced IL1 and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition [Elektronische Daten] [Paramjit Tappia, Robert Grimble] The study investigated the changes in individual molecular species in PE and the effects of a variety of dietary fats with varying proportions of saturated and unsaturated fatty acids on membrane composition, eicosanoid production and cytokine production in thioglycollate-elicited rat macrophages. The data obtained indicates that the greatest degree of modulation by dietary fats on cytokine production was observed after 8 weeks feeding and at this time, the total diacyl species containing linoleic acid (18:2 n-6) and arachidonic acid (20:4 n-6) at the sn-2 position related in a curvilinear fashion to total 18:2 n-6 intake and that IL1 and IL6 production related in a curvilinear fashion to the total diacyl species with 20:4 and 18:2 at the sn-2 position. After 4 weeks of feeding, fish and olive oils enhanced production of IL6 and LTB4, however, while IL1 production, after 8 weeks of dietary treatment, was greatest from macrophages of animals fed corn and olive oils, PGE2 production was greatest in the former group and LTB4 production in the latter. Thus an eicosanoid effect may explain the modulatory influence of olive oil and IL1 production but, cannot explain the effect of corn oil on production of the cytokine. The data from the present study provides some insight into how dietary fats could provide therapy for conditions in which inflammatory cytokines are implicated. Kluwer Academic Publishers, 1996 macrophage nationallicence membrane composition nationallicence interleukin-1 nationallicence interleukin-6 nationallicence prostaglandin E2 nationallicence leukotriene B4 nationallicence Tappia Paramjit Department of Human Nutrition, University of Southampton, Bassett Crescent East, S016 7PX, Southampton, UK aut Grimble Robert Department of Human Nutrition, University of Southampton, Bassett Crescent East, S016 7PX, Southampton, UK aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/2(1996-12-01), 135-143 0300-8177 165:2<135 1996 165 11010 https://doi.org/10.1007/BF00229475 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00229475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tappia Paramjit Department of Human Nutrition, University of Southampton, Bassett Crescent East, S016 7PX, Southampton, UK aut NATIONALLICENCE 700 1- Grimble Robert Department of Human Nutrition, University of Southampton, Bassett Crescent East, S016 7PX, Southampton, UK aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 165/2(1996-12-01), 135-143 0300-8177 165:2<135 1996 165 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer