caa a22 4500 477120725 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408635 doi (NATIONALLICENCE)springer-10.1007/BF00408635 Vornanen Matti Department of Biology, University of Joensuu, P.O. Box 111 80101, Joensuu, Finland aut Excitation-contraction coupling of the developing rat heart [Elektronische Daten] [Matti Vornanen] Postnatal maturation of rat heart is characterized by increases in force production, velocity of shortening and heart rate. Simultaneously with the enhanced cardiac power production the size of ventricular myocytes markedly increases. Parallel increase in cardiac rate functions and cells size would be expected to require reorganization of cardiac Ca regulation so that adequate rate of Ca release and uptake can be maintained. In accordance with this the source of activator Ca shifts from extracellular space to intracellular stores within the first four or five weeks of postnatal life. Calcium handling of sarcoplasmic reticulum and sarcolemma change in complementary manner so that diminishing sarcolemmal Ca transport is compensated with enhanced Ca release and sequestration by the sarcoplasmic reticulum during the early postnatal development of rat heart. These functional changes are partly due to reciprocal alterations in surface area of sarcolemma and sarcoplasmic reticulum, partly due to age-dependent changes in the expression of different transport systems and their kinetic properties. Kluwer Academic Publishers, 1996 excitation-contraction coupling nationallicence postnatal development nationallicence rat heart nationallicence sarcoplasmic reticulum nationallicence sarcolemma nationallicence Na-Caexchange nationallicence Ca current nationallicence Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 5-11 0300-8177 163-164:1<5 1996 163-164 11010 https://doi.org/10.1007/BF00408635 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408635 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Vornanen Matti Department of Biology, University of Joensuu, P.O. Box 111 80101, Joensuu, Finland aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 5-11 0300-8177 163-164:1<5 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer