caa a22 4500 47712075X CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408673 doi (NATIONALLICENCE)springer-10.1007/BF00408673 Differences in response to activation of adenylyl cyclase by various stimulants in human myocardium [Elektronische Daten] [Sixtus Hynie, Věra Klenerová, Martha Caicedo, Milan Šamánek] The response of adenylyl cyclase complex in human atrial tissue removed at corrective surgery of normoxemic and hypoxemic congenital heart defects in children to various stimulants was evaluated and related to the oxygenation state of the myocardium. When comparing response to stimulation in normoxemic and hypoxemic atria a higherbasal as well as stimulated adenylyl cyclase activity was found in hypoxemic atria; an insignificant stimulatory effect of isoprenaline in normoxemic hearts became significant in the atria of hypoxemic patients. Hypoxemic samples also showed two times higher activity when the total catalytic activity was evaluated by the stimulation with forskolin. Higher stimulatory effect of Gpp/NH/p was also observed in hypoxemic than in normoxemic state. Increased adenylyl cyclase activity might represent one of adaptive mechanisms to hypoxemia in patients with congenital heart defects. Kluwer Academic Publishers, 1996 adenylyl cyclase nationallicence congenital heart tissue nationallicence hypoxemia nationallicence atrial tissue nationallicence Hynie Sixtus Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut Klenerová Věra Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut Caicedo Martha Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut Šamánek Milan Center of Pediatric Cardiology, FN-Motol, Prague, Czech Republic aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 329-333 0300-8177 163-164:1<329 1996 163-164 11010 https://doi.org/10.1007/BF00408673 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408673 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hynie Sixtus Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut NATIONALLICENCE 700 1- Klenerová Věra Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut NATIONALLICENCE 700 1- Caicedo Martha Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague, Czech Republic aut NATIONALLICENCE 700 1- Šamánek Milan Center of Pediatric Cardiology, FN-Motol, Prague, Czech Republic aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 329-333 0300-8177 163-164:1<329 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer