caa a22 4500 477120792 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408644 doi (NATIONALLICENCE)springer-10.1007/BF00408644 Regulation of the slow Ca++ channels of myocardial cells [Elektronische Daten] [N. Sperelakis, Y. Katsube, H. Yokoshiki, H. Sada, K. Sumii] Contraction of the heart is regulated by a number of mechanisms, such as neurotransmitters, hormones, autacoids, pH, intracellular ATP, and Ca++ ions. These actions are mediated, at least in part, by actions on the sarcolemmal slow (L-type) Ca++ channels, exerted directly or indirectly. The major mechanisms for the regulation of the slow Ca++ channels of myocardial cells includes the following. cAMP/PK-A phosphorylation stimulates the slow Ca's channel activity, whereas cGMP/PK-G phosphorylation inhibits. DAG/PK-C phosphorylation and tyrosine kinase phosphorylation are suggested to stimulate the slow Ca++ channel activity. Intracellular application of Gsα protein increases the slow Ca++ currents (ICa(L)). Lowering of intracellular ATP inhibits ICa(L). Acidosis and increase in [Ca]i inhibits ICa(L). A number of changes in the Ca++ channels also occur during development and aging. Thus, it appears that the slow Ca++ channel is a complex structure, including perhaps several associated regulatory proteins, which can be regulated by a number of extrinsic and intrinsic factors, and thereby control can be exercised over the force of contraction of the heart. Kluwer Academic Publishers, 1996 slow (L-type) Ca++ channels nationallicence Ca++ currents nationallicence myocardial cells nationallicence phosphorylation nationallicence ATP regulation nationallicence developmental changes nationallicence Sperelakis N. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut Katsube Y. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut Yokoshiki H. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut Sada H. Department of Pharmacology, Yamaguchi University, Japan aut Sumii K. Department of Physiology, Hiroshima University, Japan aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 85-98 0300-8177 163-164:1<85 1996 163-164 11010 https://doi.org/10.1007/BF00408644 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408644 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sperelakis N. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Katsube Y. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Yokoshiki H. Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Sada H. Department of Pharmacology, Yamaguchi University, Japan aut NATIONALLICENCE 700 1- Sumii K. Department of Physiology, Hiroshima University, Japan aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 85-98 0300-8177 163-164:1<85 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer