caa a22 4500 477120865 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408672 doi (NATIONALLICENCE)springer-10.1007/BF00408672 Significance of the adenine nucleotide translocator in the pathogenesis of viral heart disease [Elektronische Daten] [Heinz-Peter Schultheiss, Karsten Schulze, Andrea Dörner, Benjamin Franklin] We found recently autoantibodies against the adenine nucleotide translocator (ANT), a carrier in the inner mitochondrial membrane, in sera of patients with myocarditis and dilated cardiomyopathy. To elucidate whether these antibodies are of pathophysiological importance, we investigated the function and expression of the adenine nucleotide translocator (ANT) in the heart muscle tissue of patients suffering from myocarditis and DCM. We found a markedly lowered transport capacity of the translocator accompanied by an elevation in total ANT protein content. The alteration in ANT protein amount is caused by an ANT isoform shift characterized by an increase in ANT 1 isoform protein associated with a decrease in ANT 2 isoform and an unchanged ANT 3 content. It could be shown that the isoform shift is not a progressive process during the disease period but an event in the early period of illness which becomes permanent. Simulating the effect of pathogenetic factors of autoimmunological diseases, we infected A/J mice with the enterovirus Cox-sackie B3 and immunized guinea pigs with myocardial ANT protein. Both treatments led to autoimmunological responds and to a lowered myocardial transport capacity of ANT, to a disturbed energy metabolism and consequently to a depression of heart function. Kluwer Academic Publishers, 1996 Schultheiss Heinz-Peter Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut Schulze Karsten Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut Dörner Andrea Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut Franklin Benjamin Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 319-327 0300-8177 163-164:1<319 1996 163-164 11010 https://doi.org/10.1007/BF00408672 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408672 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schultheiss Heinz-Peter Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut NATIONALLICENCE 700 1- Schulze Karsten Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut NATIONALLICENCE 700 1- Dörner Andrea Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut NATIONALLICENCE 700 1- Franklin Benjamin Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berling, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 319-327 0300-8177 163-164:1<319 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer