caa a22 4500 477120881 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408651 doi (NATIONALLICENCE)springer-10.1007/BF00408651 Heart glycogen content and isoprenaline-induced myocardial lesions [Elektronische Daten] [Miroslav Mraz, Sixtus Hynie] The role of glycogen content in the heart for the development of isoprenaline-induced myocardial lesions (IML) was studied in Wistar rats and in two inbred rat strains: In IR rats (resistant to the development of IML) and in IS rats (sensitive to IML development). Glycogen content in the heart can be dramatically lowered or increased by various interventions. IML develop during the period of very low heart glycogen content (about 0.6 mg.g−1) induced by isoprenaline administration. In animals with increased resistance to IML, either due to genetic factors or induced by isoprenaline pretreatment a high glycogen content in the heart is found (up to 7.5 mg.g−1). The increase of resistance to IML development and increased glycogen content induced by isoprenaline pretreatment were accompanied by lower basal or ISO-, guanylylimidodiphosphate- (Gpp/NH/p) and forskolin-stimulated activities of adenylyl cyclase. On the other hand, these parameters did not differ between IR and IS rats in spite of the presence of significant differences in the resistance to the development of IML and in heart glycogen content in these two rats strains. These results suggest that genetically determined differences between two inbred rat strains in the resistance of the heart to the development of IML and in the heart glycogen content are caused by factors which are independent of the receptor-adenylyl cyclase complex and are therefore different from those involved in the increase of resistance and glycogen content due to isoprenaline pretreatment. Kluwer Academic Publishers, 1996 heart nationallicence glycogen nationallicence adenylyl cyclase nationallicence catecholamine heart failure nationallicence Mraz Miroslav Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague 2, Czech Republic aut Hynie Sixtus Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague 2, Czech Republic aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 145-149 0300-8177 163-164:1<145 1996 163-164 11010 https://doi.org/10.1007/BF00408651 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408651 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mraz Miroslav Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Hynie Sixtus Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00, Prague 2, Czech Republic aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 145-149 0300-8177 163-164:1<145 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer