caa a22 4500 477120903 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00408666 doi (NATIONALLICENCE)springer-10.1007/BF00408666 Myocardial fibrosis and right ventricular function of heterotopically transplanted hearts in rats treated with cyclosporin [Elektronische Daten] [František Kolář, František Papoušek, Cathy MacNaughton, Václav Pelouch, Marie Milerová, Borivoj Korecky] The aim was to determine whether treatment of rats with cyclosporin A (CsA) leads to deleterious side effects on heterotopically iso- or allotransplanted hearts when compared with recipient native in situ hearts. Four experimental groups were employed: inbred (Lewis) rats receiving either no immunosuppression or CsA at a dose of 15 mg.kg−1 per day for 7 days after surgery, and outbred (Wistar) rats receiving CsA at the same daily dose for either 7 or 21 days. One month following surgery, the mass of all transplanted hearts decreased and resulting atrophy was associated with relative myocardial fibrosis. Treatment with CsA significantly increased the concentration and content of collagen in the right and left ventricles of all transplanted and recipient hearts. No appreciable difference was observed between corresponding hearts of inbred and outbred groups receiving the identical dose of CsA, and between hearts in outbred groups treated for either 7 or 21 days. No signs of right ventricular mechanical dysfunction, as assessed on the isolated perfused ‘working' preparation, were observed after CsA treatment in both transplanted and recipient hearts. The maximal steady state developed pressure (RVDevP) and the rate of its development [(+dP/dt)max] were slightly higher in transplants than in the corresponding recipients, and in CsA-treated versus untreated hearts, while the index of contractile state [(+dP/dt)/P] was similar in all groups. The data suggest that treatment of rats with CsA can induce a similar degree of fibrosis both in heterotopic cardiac transplants and in recipient native hearts without impairment of their contractile performance. Kluwer Academic Publishers, 1996 heterotopic transplantation nationallicence cardiac atrophy nationallicence ventricular function nationallicence collagen nationallicence cyclosporin nationallicence Kolář František Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut Papoušek František Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut MacNaughton Cathy Department of Physiology, University of Ottawa Health Sciences Center, K1H 8M5, Ottawa, Ontario, Canada aut Pelouch Václav Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut Milerová Marie Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut Korecky Borivoj Department of Physiology, University of Ottawa Health Sciences Center, K1H 8M5, Ottawa, Ontario, Canada aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 253-260 0300-8177 163-164:1<253 1996 163-164 11010 https://doi.org/10.1007/BF00408666 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00408666 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolář František Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut NATIONALLICENCE 700 1- Papoušek František Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut NATIONALLICENCE 700 1- MacNaughton Cathy Department of Physiology, University of Ottawa Health Sciences Center, K1H 8M5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Pelouch Václav Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut NATIONALLICENCE 700 1- Milerová Marie Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czech Republic aut NATIONALLICENCE 700 1- Korecky Borivoj Department of Physiology, University of Ottawa Health Sciences Center, K1H 8M5, Ottawa, Ontario, Canada aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www.wkap.nl 163-164/1(1996-03-01), 253-260 0300-8177 163-164:1<253 1996 163-164 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer