caa a22 4500 477120938 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00248459 doi (NATIONALLICENCE)springer-10.1007/BF00248459 tBHP induced in vitro swelling of rat liver mitochondria [Elektronische Daten] [Poonam Kakkar, Sudhir Mehrotra, P. Viswanathan] Tert-butyl hydroperoxide induced swelling of freshly isolated rat liver mitochondria was inhibited by butylated hydroxytoluene, butylated hydroxyanisole and α-tocopherol by acting at the initial phase. EDTA was more effective than EGTA in reducing the initial swelling and so were desferal and bipyrridyl. Spermine, an allosteric activator of calcium uptake, enhanced swelling whereas lanthanum and ruthenium red, the Ca2+ uniport blockers, reduced it. Inhibition of phospholipase A2 by dibucaine and Ca2+ activated proteases by antipain and leupeptin also reduced t-BHP induced swelling. The data indicate that peroxidative mitochondrial swelling involves an iron mediated initial rapid phase and a subsequent calcium dependent propagation phase. Kluwer Academic Publishers, 1996 free radicals nationallicence oxidative stress nationallicence mitochondrial swelling nationallicence tert-butyl hydroperoxide nationallicence calcium deregulation nationallicence Kakkar Poonam Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut Mehrotra Sudhir Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut Viswanathan P. Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 154/1(1996-03-01), 39-45 0300-8177 154:1<39 1996 154 11010 https://doi.org/10.1007/BF00248459 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00248459 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kakkar Poonam Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- Mehrotra Sudhir Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- Viswanathan P. Ecotoxicology Section, Industrial Toxicology Research Centre, M.G. Marg, P. Box-80, 226 001, Lucknow, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 154/1(1996-03-01), 39-45 0300-8177 154:1<39 1996 154 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer