caa a22 4500 477120962 CHVBK 20180405111636.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00248457 doi (NATIONALLICENCE)springer-10.1007/BF00248457 Oxygen-dependent Leishmanicidal activity of stimulated macrophages [Elektronische Daten] [R. Chakraborty, S. Mukherjee, M. Basu] Peritoneal macrophages pretreated with different stimulants were analysed and compared with their respective controls for their ability to kill intracellular pathogenic L. donovani, (MHOM/IN/1983/AG83) an isolate from Indian subcontinent. Stimulation of macrophages by zymosan showed a higher microbicidal activity as compared to that by PMA. A correlation between microbicidal activity of the macrophages and the parameters related to respiratory burst activity such as liberation of 02 −, production of H202 and consumption of 02 was sought. All the parameters showed a decrease in case of infected macrophages in comparison to those of the non-infected ones. Thus, it is possible that the impairment of macrophage activation by intracellular Leishmania contributes to their survival in the toxic environment of the host. KluwerAcademic Publishers, 1996 Leishmania donovani nationallicence respiratory burst nationallicence microbicidal activity nationallicence 02 : superoxide anion nationallicence H202 : hydrogen peroxide nationallicence PMA : phorbol 12-myristate 13-acetate nationallicence PHPA : phydroxylphenylacetic acid nationallicence Hepes : N-2-hydroxyethyl piperazine-N-2-ethyl sulphonic acid nationallicence Chakraborty R. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut Mukherjee S. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut Basu M. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 154/1(1996-03-01), 23-29 0300-8177 154:1<23 1996 154 11010 https://doi.org/10.1007/BF00248457 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00248457 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chakraborty R. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut NATIONALLICENCE 700 1- Mukherjee S. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut NATIONALLICENCE 700 1- Basu M. Leishmania Group, Biomembrane Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, 700032, Calcutta, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 154/1(1996-03-01), 23-29 0300-8177 154:1<23 1996 154 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer