caa a22 4500 477125395 CHVBK 20180405111647.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1007/BF02505331 doi (NATIONALLICENCE)springer-10.1007/BF02505331 Immunohistochemically detected HER-2/neu-expression and prognosis in endometrial carcinoma [Elektronische Daten] [J. Backe, A. Gassel, S. Krebs, T. Müller, H. Caffier] Expression of the HER-2/neu proto-oncogene product was looked for immunohistochemically in 222 endometrial carcinomas in a retrospective followup study. The intensity of protein expression was correlated with patient survival. Median follow-up time was 4.8 years. In 109 (49%) of 222 endometrial carcinomas there was aberrant expression of HER-2/neu. HER-2/neu-expression did not correlate with p53-expression and proliferation rate, as determined immunohistochemically by the monoclonal antibody Ki-S1. In univariate statistical analysis aberrant HER-2/neu expression was not predictive of adjusted survival (p=0.18) and of disease-free survival (p=0.42). In multivariate analysis HER-2/neu-expression was not found to be an independent prognosticator (p=0.099) as compared to FIGO-stage (p=0.0001), histologic grade (p=0.00099) and proliferation rate (p=0.0013). Therefore immunohistochemically detected expression of HER-2/neu seems not to be a clinical prognosticator in endometrial cancer. Springer-Verlag, 1997 Immunohistochemistry nationallicence HER-2/neu nationallicence p53 nationallicence Ki-S1 nationallicence Endometrial carcinoma nationallicence Backe J. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut Gassel A. Institute of Pathology, University of Würzburg, Germany aut Krebs S. Institute of Pathology, University of Würzburg, Germany aut Müller T. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut Caffier H. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 259/4(1997-07-01), 189-195 0932-0067 259:4<189 1997 259 404 https://doi.org/10.1007/BF02505331 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02505331 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Backe J. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut NATIONALLICENCE 700 1- Gassel A. Institute of Pathology, University of Würzburg, Germany aut NATIONALLICENCE 700 1- Krebs S. Institute of Pathology, University of Würzburg, Germany aut NATIONALLICENCE 700 1- Müller T. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut NATIONALLICENCE 700 1- Caffier H. Department of Obstetrics and Gynecology, University of Würzburg, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 259/4(1997-07-01), 189-195 0932-0067 259:4<189 1997 259 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer