caa a22 4500 477125433 CHVBK 20180405111647.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1007/BF02505312 doi (NATIONALLICENCE)springer-10.1007/BF02505312 Prevalence of human papillomavirus DNA in cervical tissue. Retrospective analysis of 855 cervical biopsies [Elektronische Daten] [J. Backe, T. Roos, L. Mulfinger, J. Martius] The histopathologic features of 855 cervical biopsies were correlated with the presence of human papillomavirus DNA using in situ hybridization (ISH) with biotin labeled type specific probes for Human Papilloma Virus (HPV) types 6, 11, 16, 18, 31, 33 and 51. HPV-DNA was found in 18% (13/72) of cervical intraeptihelial neoplasia I (CIN I), 30% (35/115) of CIN II, 28% (57(206) of CIN III, in 84% (21/25) of flat condyloma and in 13% (15/112) of normal cervical tissue. HPV DNA was detectable in 11% (5/46) of cervical adenocarcinoma and in 21% (59/279) of squamous cell carcinoma (SCC) of the cervix. High risk HPV types were identified more often than low risk HPV types in CIN I, CIN II, CIN III and SCC. HPV type 16/18 predominates over HPV type 31/33/51 in CIN I, flat condyloma and in SCC. The prevalence of HPV was strongly associated with the grade of differentiation of SCC. It was identified in 59% (23/39) of well differentiated SCC, in 18% (25/142) of moderately differentiated and in 11% (11/98) of poorly differentiated SCC. Springer-Verlag, 1997 Human Papillomavirus nationallicence In situ Hybridization nationallicence CIN nationallicence Squamous cell carcinoma of the cervix nationallicence Grading nationallicence Backe J. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut Roos T. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut Mulfinger L. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut Martius J. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 259/2(1997-01-01), 69-77 0932-0067 259:2<69 1997 259 404 https://doi.org/10.1007/BF02505312 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02505312 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Backe J. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut NATIONALLICENCE 700 1- Roos T. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut NATIONALLICENCE 700 1- Mulfinger L. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut NATIONALLICENCE 700 1- Martius J. Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, D-97080, Würzburg, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 259/2(1997-01-01), 69-77 0932-0067 259:2<69 1997 259 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer