caa a22 4500 477125484 CHVBK 20180405111648.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1007/BF02505316 doi (NATIONALLICENCE)springer-10.1007/BF02505316 Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature [Elektronische Daten] [S. Remadi, B. Lifschitz-Mercer, H. Ben-Hur, R. Dgani, B. Czernobilsky] Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome. Springer-Verlag, 1997 Placental site trophoblastic tumor nationallicence Metastasis nationallicence Remadi S. Institut de Pathologie Clinique, Hôpital Cantonal Universitaire de Genève, 1, rue Michel Servet, CH-1211, Genève 4, Switzerland aut Lifschitz-Mercer B. Institute of Pathology, Sourasky Medical Center, Tel Aviv, Israel aut Ben-Hur H. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut Dgani R. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut Czernobilsky B. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut Archives of Gynecology and Obstetrics Springer-Verlag 259/2(1997-01-01), 97-103 0932-0067 259:2<97 1997 259 404 https://doi.org/10.1007/BF02505316 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02505316 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Remadi S. Institut de Pathologie Clinique, Hôpital Cantonal Universitaire de Genève, 1, rue Michel Servet, CH-1211, Genève 4, Switzerland aut NATIONALLICENCE 700 1- Lifschitz-Mercer B. Institute of Pathology, Sourasky Medical Center, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Ben-Hur H. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut NATIONALLICENCE 700 1- Dgani R. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut NATIONALLICENCE 700 1- Czernobilsky B. Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 259/2(1997-01-01), 97-103 0932-0067 259:2<97 1997 259 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer