caa a22 4500 477125549 CHVBK 20180405111648.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1012071904673 doi (NATIONALLICENCE)springer-10.1023/A:1012071904673 Near-Infrared Spectroscopy as a Nondestructive Alternative to Conventional Tablet Hardness Testing [Elektronische Daten] [Karen Morisseau, Christopher Rhodes] Purpose. Near-infrared reflectance Spectroscopy (NIRS) was used to evaluate and quantify the effect of compression force on the NIR spectra of tablets. Methods. Flat, white tablets with no orientation (scoring, etc.) were manufactured on a Stokes Rotary Tablet Press. NIRS was used to predict tablet hardness on the following four formulations and one placebo matrix: hydrochlorothiazide (HCTZ) 15% and 20% in a placebo matrix (microcrystalline cellulose and magnesium stearate), and chlorpheniramine maleate (CTM) 2% and 6% in a placebo matrix. Five or six levels of tablet hardness from 2 to 12 kg were used for each formulation. Laboratory hardness data was compared to NIR reflectance data using a NIRSystems Rapid Content Analyzer®. Multiple linear regression and partial least squares regression techniques were used to determine the relationship between tablet hardness and NIRS spectra. Results. An increase in tablet hardness produced an upward shift (increase in absorbance) in the NIRS spectra. A series of equations was developed by calibrating tablet hardness data against NIR reflectance response for each formulation. The results of NIRS hardness prediction were at least as precise as the laboratory hardness test (SE = 0.32). Conclusions. A NIRS method is presented which has the potential as an alternative to conventional hardness testing of tablets. Plenum Publishing Corporation, 1997 near-infrared Spectroscopy nationallicence NIRS nationallicence tablet hardness nationallicence compression force nationallicence Rapid Content Analyzer nationallicence calibration nationallicence Morisseau Karen Applied Pharmaceutical Sciences, University of Rhode Island, 02881, Kingston, Rhode Island aut Rhodes Christopher Applied Pharmaceutical Sciences, University of Rhode Island, 02881, Kingston, Rhode Island aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/1(1997-01-01), 108-111 0724-8741 14:1<108 1997 14 11095 https://doi.org/10.1023/A:1012071904673 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012071904673 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morisseau Karen Applied Pharmaceutical Sciences, University of Rhode Island, 02881, Kingston, Rhode Island aut NATIONALLICENCE 700 1- Rhodes Christopher Applied Pharmaceutical Sciences, University of Rhode Island, 02881, Kingston, Rhode Island aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/1(1997-01-01), 108-111 0724-8741 14:1<108 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer