caa a22 4500 477125603 CHVBK 20180405111648.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1012055401038 doi (NATIONALLICENCE)springer-10.1023/A:1012055401038 Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis [Elektronische Daten] [Patrizia Santi, Paolo Colombo, Ruggero Bettini, Pier Catellani, Antonia Minutello, Nadia Volpato] Purpose. The aim of the work was to study iontophoretic transdermal administration of salmon calcitonin (sCt) in rabbits, with particular attention to drug reservoir composition. A dry sCt disc, to be dissolved on the application site, was used for preparing the reservoir for transdermal iontophoresis. As a reference drug reservoir, a pad wetted with drug solution was used. Methods. Experiments were done in rabbits depositing 100 IU of salmon calcitonin on skin and applying anodal iontophoresis. Serum calcium concentration was measured during iontophoresis, passive diffusion and after i.v. administration. Parameters such as pH value and reservoir type were examined. Results. Transdermal iontophoresis of sCt elicited a decrease in the serum calcium level, whereas, in the absence of electric current, no significant fall was measured. Using the reservoir prepared from drug solution, anodal iontophoresis at pH 4.2 was more effective than at pH 7.4, probably due to higher sCt net positive charge. Using the reservoir prepared from dry disc, similar kinetics and extent of drug effect were observed at both pH values. The reservoir prepared from solid drug deposit concentrated sCt next to the skin. Conclusions. Anodal iontophoresis for transdermal calcitonin administration shows therapeutical applicability. The type of reservoir is an important parameter affecting sCt transdermal iontophoresis. Plenum Publishing Corporation, 1997 iontophoresis nationallicence transdermal delivery nationallicence calcitonin nationallicence reservoir nationallicence peptide nationallicence Santi Patrizia Pharmaceutical Department, University of Parma, Via delle Scienze, 43100, Parma, Italy aut Colombo Paolo aut Bettini Ruggero aut Catellani Pier aut Minutello Antonia aut Volpato Nadia Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, UFRJ, Rio de Janeiro, Brazil aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/1(1997-01-01), 63-66 0724-8741 14:1<63 1997 14 11095 https://doi.org/10.1023/A:1012055401038 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012055401038 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Santi Patrizia Pharmaceutical Department, University of Parma, Via delle Scienze, 43100, Parma, Italy aut NATIONALLICENCE 700 1- Colombo Paolo aut NATIONALLICENCE 700 1- Bettini Ruggero aut NATIONALLICENCE 700 1- Catellani Pier aut NATIONALLICENCE 700 1- Minutello Antonia aut NATIONALLICENCE 700 1- Volpato Nadia Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, UFRJ, Rio de Janeiro, Brazil aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/1(1997-01-01), 63-66 0724-8741 14:1<63 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer