caa a22 4500 477126006 CHVBK 20180405111649.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1012194504982 doi (NATIONALLICENCE)springer-10.1023/A:1012194504982 Theory of Force Transducer Design Optimization for Die Wall Stress Measurement During Tablet Compaction: Optimization and Validation of Split-Web Die Using Finite Element Analysis [Elektronische Daten] [Chuntien Yeh, Syed Altaf, Stephen Hoag] Purpose. 1) To illustrate how computer aided engineering stress analysis can be used to improve the transducer design process for tablet press instrumentation; 2) to use these optimal design procedures for the geometric optimization of a cylindrical, segmented, and a novel split-web die design. Discussion includes the selection of optimal die wall thickness, segment cutting angle, strain gage placement, Wheatstone bridge configuration, and the influence of tablet height and position within the die on signal output. Methods. Stress analysis was done with a finite element analysis (FEA) software package running on a personal computer. Results. For the segmented die, the admissible range of die wall thicknesses depends upon cutting angle; the signal output is non-linear because the stress distribution in the die wall is influenced by tablet height and position within the die. For the split-web die, the optimal configuration consists of a 1/8 in. sensing web with a strain gage located at the peak of the sensing-web arch. This prototype had a linear calibration curve (r2 = 0.999) with no hysteresis. Radial versus axial stress transmission curves for: starch and sodium chloride were consistent with literature data. Conclusions. Finite element analysis (FEA) is a useful numerical tool for the systematic optimization of tablet press instrumentation. By enclosing the sensing web of a three layered die design in a cylinder, the split-web design can be directly mounted without modification of the die table. Plenum Publishing Corporation, 1997 force transducer design and design optimization nationallicence split-web die nationallicence design-by-analysis approach nationallicence finite element analysis (FEA) nationallicence die wall stress measurement nationallicence tablet compaction nationallicence Yeh Chuntien Freightliner Co., 4747 N Channel Ave., PO Box 3849, 97208, Portland, Oregon aut Altaf Syed Cibus Pharmaceutical Inc., 887 Mitten Rd., 94010, Burlingame, California aut Hoag Stephen School of Pharmacy, University of Maryland at Baltimore, 20 N Pine Street, 21201, Baltimore, Maryland aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/9(1997-09-01), 1161-1170 0724-8741 14:9<1161 1997 14 11095 https://doi.org/10.1023/A:1012194504982 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012194504982 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yeh Chuntien Freightliner Co., 4747 N Channel Ave., PO Box 3849, 97208, Portland, Oregon aut NATIONALLICENCE 700 1- Altaf Syed Cibus Pharmaceutical Inc., 887 Mitten Rd., 94010, Burlingame, California aut NATIONALLICENCE 700 1- Hoag Stephen School of Pharmacy, University of Maryland at Baltimore, 20 N Pine Street, 21201, Baltimore, Maryland aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/9(1997-09-01), 1161-1170 0724-8741 14:9<1161 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer