caa a22 4500 47712626X CHVBK 20180405111650.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1023/A:1012139530965 doi (NATIONALLICENCE)springer-10.1023/A:1012139530965 Modeling in Frequency Domain Used for Assessment of In Vivo Dissolution Profile [Elektronische Daten] [Mária Ďurišová, Ladislav Dedík] Purpose. To present a model-dependent approach for the assessment of the in vivo drug dissolution profile based on in vitrodata for the multiple unit dosage form, as an alternative to the numerical method proposed in the study by Hayashi et al, Pharm. Res. 12:1333−1337 (1995). Methods. The data for aspirin granules administered to healthy subjects obtained in the above mentioned study were re-evaluated. The subject dissolution system was considered to consist of two subsystems connected in series, i.e. the subsystem describing the gastric-emptying process and the subsystem describing the intestinal dissolution process. The frequency response method was used to model the subject dissolution system. Results. The model in vivodissolution profile of aspirin, assessed as the integral of the model weighting function of the subject dissolution system, was in agreement with the in vivo cumulative absorption profile calculated by the Wagner-Nelson method. Conclusions. Comparison of dynamic properties of the subject dissolution system with the subsystem describing the gastric-emptying process yielded quantitative confirmation of the decisive role of the gastric-emptying process in the in vivodrug dissolution after administration in the multi unit dosage form. Plenum Publishing Corporation, 1997 aspirin nationallicence pharmacokinetics nationallicence dissolution nationallicence weighting function nationallicence convolution nationallicence bioequivalence nationallicence Ďurišová Mária Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 16, Bratislava, Slovak Republic aut Dedík Ladislav Faculty of Mechanical Engineering, Department of Automation and Measurement, Slovak Technical University, Námestie slobody 17, 812 31, Bratislava, Slovak Republic aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/7(1997-07-01), 860-864 0724-8741 14:7<860 1997 14 11095 https://doi.org/10.1023/A:1012139530965 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012139530965 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ďurišová Mária Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 16, Bratislava, Slovak Republic aut NATIONALLICENCE 700 1- Dedík Ladislav Faculty of Mechanical Engineering, Department of Automation and Measurement, Slovak Technical University, Námestie slobody 17, 812 31, Bratislava, Slovak Republic aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/7(1997-07-01), 860-864 0724-8741 14:7<860 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer