caa a22 4500 477126588 CHVBK 20180405111651.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1012167410376 doi (NATIONALLICENCE)springer-10.1023/A:1012167410376 Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions [Elektronische Daten] [Lynne Taylor, George Zografi] Purpose. To study the molecular structure of indomethacin-PVP amorphous solid dispersions and identify any specific interactions between the components using vibrational spectroscopy. Methods. Solid dispersions of PVP and indomethacin were prepared using a solvent evaporation technique and IR and FT-Raman spectra were obtained. Results. A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indomethacin indicated that the amorphous phase exists predominantly as dimers. The hydrogen bonding of α indomethacin is not as dimers. Addition of PVP to amorphous indomethacin increased the intensity of the infrared band assigned to non-hydrogen bonded carbonyl. Con-comitantly, the PVP carbonyl stretch appeared at a lower wavenumber indicating hydrogen bonding. Model solvent systems aided spectral interpretation. The magnitude of the spectral changes were comparable for an indomethacin-PVP solid dispersion and a solution of indomethacin in methylpyrrolidone at the same weight percent. Conclusions. Indomethacin interacts with PVP in solid dispersions through hydrogen bonds formed between the drug hydroxyl and polymer carbonyl resulting in disruption of indomethacin dimers. PVP may influence the crystallisation kinetics by preventing the self association of indomethacin molecules. The similarity of results for solid dispersions and solutions emphasises the 'solution' nature of this binary amorphous state. Plenum Publishing Corporation, 1997 solid-state interaction nationallicence spectroscopy nationallicence amorphous nationallicence solid dispersion nationallicence Taylor Lynne aut Zografi George School of Pharmacy, University of Madison-Wisconsin, 425 North Charter Street, 53706, Madison, Wisconsin aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/12(1997-12-01), 1691-1698 0724-8741 14:12<1691 1997 14 11095 https://doi.org/10.1023/A:1012167410376 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012167410376 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taylor Lynne aut NATIONALLICENCE 700 1- Zografi George School of Pharmacy, University of Madison-Wisconsin, 425 North Charter Street, 53706, Madison, Wisconsin aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/12(1997-12-01), 1691-1698 0724-8741 14:12<1691 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer