caa a22 4500 477126715 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1012179813102 doi (NATIONALLICENCE)springer-10.1023/A:1012179813102 Inulin Hydrogels as Carriers for Colonic Drug Targeting: I. Synthesis and Characterization of Methacrylated Inulin and Hydrogel Formation [Elektronische Daten] [Liesbeth Vervoort, Guy Van den Mooter, Patrick Augustijns, Roger Busson, Suzanne Toppet, Renaat Kinget] Purpose. Vinyl groups were introduced in inulin chains in order to form hydrogels of this sugar polymer by free radical polymerization. Methods. Inulin was reacted with glycidyl methacrylate in N,N-dimethylformamide in the presence of 4-dimethylaminopyridine as catalyst. 1H and 13C NMR spectroscopy were used for the characterization of the obtained reaction product. Solid state 13C NMR spectroscopy revealed the conversion of the incorporated vinyl groups into covalent cross-links upon free radical polymerization of aqueous solutions of the derivatized inulin. Results. During reaction of inulin with glycidyl methacrylate, transesterification occurred, leading to the direct attachment of the methacryloyl group to inulin. Consequently, the obtained reaction product is methacrylated inulin. The extent of chemical modification of inulin could be tuned by varying the molar ratio of glycidyl methacrylate to inulin in the reaction mixture. Aqueous solutions of methacrylated inulin were converted into cross-linked hydrogels by free radical polymerization using ammonium persulphate and N,N,N′,N′-tetramethylethylenediamine as initiating system. Conclusions. Inulin hydrogels can be formed by free radical polymerization of aqueous solutions of methacrylated inulin. Plenum Publishing Corporation, 1997 inulin nationallicence glycidyl methacrylate nationallicence hydrogels nationallicence NMR spectroscopy nationallicence Vervoort Liesbeth Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut Van den Mooter Guy Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut Augustijns Patrick Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut Busson Roger Laboratorium voor Medicinale Chemie, K.U. Leuven, Leuven, Belgium aut Toppet Suzanne Afdeling Organische Synthese, K.U. Leuven, Leuven, Belgium aut Kinget Renaat Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/12(1997-12-01), 1730-1737 0724-8741 14:12<1730 1997 14 11095 https://doi.org/10.1023/A:1012179813102 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012179813102 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vervoort Liesbeth Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Van den Mooter Guy Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Augustijns Patrick Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Busson Roger Laboratorium voor Medicinale Chemie, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Toppet Suzanne Afdeling Organische Synthese, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 700 1- Kinget Renaat Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven, Leuven, Belgium aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/12(1997-12-01), 1730-1737 0724-8741 14:12<1730 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer