caa a22 4500 477126820 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012037819211 doi (NATIONALLICENCE)springer-10.1023/A:1012037819211 Theory and Computer Programs for Calculating Solution pH, Buffer Formula, and Buffer Capacity for Multiple Component System at a Given Ionic Strength and Temperature [Elektronische Daten] [Hirokazu Okamoto, Kiyoko Mori, Kumiko Ohtsuka, Hiroyuki Ohuchi, Hiroaki Ishii] Purpose. A theory and computer programs running on Microsoft® Excel for Windows for calculation of solution pH, buffer formula, and buffer capacity at a given ionic strength and temperature were developed. The theory does not limit the category of buffer components, the number of buffer components, or the number of ionizations for each buffer component. The usefulness of the programs was examined. Methods. The formulas for 7 single component buffer solutions and 2 multiple component buffer solutions composed of citrate, phosphate, Tris, borate, and glycine were calculated. The solution pH values were measured at 25, 40, 55 and 70°C for comparison with the calculated pH values. Results. Of the 108 predictions made, 96 were of pH values within ± 0.1 pH unit of the measured values, at temperatures ranging from 25°C to 70°C and at ionic strengths ranging from 0.1 M to 0.5 M. Conclusions. These programs will be useful for identifying appropriate buffer solutions at various temperatures and/or ionic strengths. Plenum Publishing Corporation, 1997 pH nationallicence buffer solution nationallicence ionic strength nationallicence computer program nationallicence Okamoto Hirokazu Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut Mori Kiyoko Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut Ohtsuka Kumiko Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut Ohuchi Hiroyuki Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut Ishii Hiroaki Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 299-302 0724-8741 14:3<299 1997 14 11095 https://doi.org/10.1023/A:1012037819211 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012037819211 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okamoto Hirokazu Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut NATIONALLICENCE 700 1- Mori Kiyoko Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ohtsuka Kumiko Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ohuchi Hiroyuki Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ishii Hiroaki Pharmacia & Upjohn, Tsukuba Research Laboratories, 23 Wadai, Tsukuba, 300-42, Ibaraki, Japan aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 299-302 0724-8741 14:3<299 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer