caa a22 4500 47712691X CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012033718302 doi (NATIONALLICENCE)springer-10.1023/A:1012033718302 Glucose-Responsive Gel from Phenylborate Polymer and Poly (Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of Borate with Amino Group in the Gel [Elektronische Daten] [Issei Hisamitsu, Kazunori Kataoka, Teruo Okano, Yasuhisa Sakurai] Purpose. To design glucose-responsive gels based on the complexation between polymers having phenylboronic acid groups and poly (vinyl alcohol). Specifically, high-glucose sensitivity at physiological pH was achieved through the interaction of phenylborate with amino groups. Method. Terpolymers of m-acrylamidophenylboronic acid, N,N-dimethylaminopropylacrylamide (DMA-PAA), and N,N-dimethylacrylamide were prepared. DMAPAA was introduced in the terpolymer to stabilize phenylborate-polyol complex at physiological pH. The effect of amino groups on complex stabilization was estimated from viscosity as well as UV spectrum measurements. Results. A good correlation was observed between complexation rate and fraction of phenylborate as well as DMAPAA in the terpolymers. In line with this increased complexation rate. UV difference spectra measurement revealed that ionization of phenylboronic acid was facilitated in the terpolymer due to the interaction with DMAPAA. Further, sensitive change in the complexation rate was demonstrated with a variation in glucose concentration, which is in sharp contrast with the poor glucose-sensitivity of the polymer without DMAPAA. Conclusions. The introduction of an amino group into phenylborate polymers was quite effective for increasing the complexation ability and the glucose responsivity at physiological pH. These results suggest the feasibility of this complex-gel system in designing a self-regulated insulin-releasing device. Plenum Publishing Corporation, 1997 boronic acid nationallicence poly(vinyl alcohol) nationallicence amino group nationallicence glucose gel nationallicence Hisamitsu Issei Department of Materials Science, and Research Institute for Biosciences, Science University of Tokyo, 2641 Yamazaki, Noda-shi, 278, Chiba, Japan aut Kataoka Kazunori Department of Materials Science, and Research Institute for Biosciences, Science University of Tokyo, 2641 Yamazaki, Noda-shi, 278, Chiba, Japan aut Okano Teruo Institute of Biomedical Engineering, Tokyo Women's Medical College, 8-1 Kawada, Shinjuku-ku, 162, Tokyo, Japan aut Sakurai Yasuhisa Institute of Biomedical Engineering, Tokyo Women's Medical College, 8-1 Kawada, Shinjuku-ku, 162, Tokyo, Japan aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 289-293 0724-8741 14:3<289 1997 14 11095 https://doi.org/10.1023/A:1012033718302 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012033718302 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hisamitsu Issei Department of Materials Science, and Research Institute for Biosciences, Science University of Tokyo, 2641 Yamazaki, Noda-shi, 278, Chiba, Japan aut NATIONALLICENCE 700 1- Kataoka Kazunori Department of Materials Science, and Research Institute for Biosciences, Science University of Tokyo, 2641 Yamazaki, Noda-shi, 278, Chiba, Japan aut NATIONALLICENCE 700 1- Okano Teruo Institute of Biomedical Engineering, Tokyo Women's Medical College, 8-1 Kawada, Shinjuku-ku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakurai Yasuhisa Institute of Biomedical Engineering, Tokyo Women's Medical College, 8-1 Kawada, Shinjuku-ku, 162, Tokyo, Japan aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 289-293 0724-8741 14:3<289 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer