caa a22 4500 477126928 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012098005098 doi (NATIONALLICENCE)springer-10.1023/A:1012098005098 Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles [Elektronische Daten] [Renad Alyautdin, Valery Petrov, Klaus Langer, Achim Berthold, Dimitry Kharkevich, Jörg Kreuter] Purpose. The possibility of using polysorbate 80-coated nanoparticles for the delivery of the water insoluble opioid agonist loperamide across the blood-brain barrier was investigated. The analgesic effect after i.v. injection of the preparations was used to indicate drug transport through this barrier. Methods. Loperamide was incorporated into PBCA nanoparticles. Drug-containing nanoparticles were coated with polysorbate 80 and injected intravenously into mice. Analgesia was then measured by the tail-flick test. Results. Intravenous injection of the particulate formulation resulted in a long and significant analgesic effect. A polysorbate 80 loperamide solution induced a much less pronounced and very short analgesia. Uncoated nanoparticles loaded with loperamide were unable to produce analgesia. Conclusions. Polysorbate 80-coated PBCA nanoparticles loaded with loperamide enabled the transport of loperamide to the brain. Plenum Publishing Corporation, 1997 loperamide nationallicence nanoparticles nationallicence polysorbate 80 nationallicence drug delivery nationallicence brain nationallicence Alyautdin Renad Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut Petrov Valery Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut Langer Klaus Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut Berthold Achim Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut Kharkevich Dimitry Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut Kreuter Jörg Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 325-328 0724-8741 14:3<325 1997 14 11095 https://doi.org/10.1023/A:1012098005098 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012098005098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alyautdin Renad Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut NATIONALLICENCE 700 1- Petrov Valery Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut NATIONALLICENCE 700 1- Langer Klaus Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Berthold Achim Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Kharkevich Dimitry Department of Pharmacology, Sechenov Medical Academy, B. Pirogovskaja St., 2/6, 119881, Moscow, Russia aut NATIONALLICENCE 700 1- Kreuter Jörg Institute of Pharmaceutical Technology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439, Frankfurt am Main, Germany aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 325-328 0724-8741 14:3<325 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer