caa a22 4500 477126960 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012058323754 doi (NATIONALLICENCE)springer-10.1023/A:1012058323754 The AERX™ Aerosol Delivery System [Elektronische Daten] [Jeff Schuster, Reid Rubsamen, Peter Lloyd, Jack Lloyd] Purpose. We describe the AERX ™ aerosol delivery system, a new, bolus inhalation device that is actuated at preprogrammed values of inspiratory flow rate and inhaled volume. We report on its in vitro characterization using a particular set of conditions used in pharmacokinetic and scintigraphic studies. Methods. Multiple doses of aerosol were delivered from single use collapsible plastic containers containing liquid formulation. The aerosol was generated by forcing the formulation under pressure through an array of 2.5 micron holes. Air was drawn through the device at 70 LPM, and the aerosol was collected onto a filter or Andersen cascade impactor. The emitted dose was quantified from the filter collection data, and the particle size distribution was obtained from the best fit log-normal distribution to the impactor data. Results. 57.0 ± 5.9% of the dose of drug placed as an aqueous solution in the 45 μL collapsible container was delivered as an aerosol (n = 40). The best fit size distribution had an MMAD = (2.95 ± 0.06) μm and a geometric standard deviation σg = 1.24 ± 0.01 (n = 6). Conclusions. The AERX aerosol delivery system generates a nearly monodisperse aerosol with the properties required for efficient and repeatable drug delivery to the lung. Plenum Publishing Corporation, 1997 drug delivery nationallicence aerosols nationallicence inhalational therapy nationallicence morphine nationallicence analgesia nationallicence Schuster Jeff Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut Rubsamen Reid Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut Lloyd Peter Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut Lloyd Jack Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 354-357 0724-8741 14:3<354 1997 14 11095 https://doi.org/10.1023/A:1012058323754 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012058323754 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schuster Jeff Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut NATIONALLICENCE 700 1- Rubsamen Reid Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut NATIONALLICENCE 700 1- Lloyd Peter Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut NATIONALLICENCE 700 1- Lloyd Jack Aradigm Corporation, 26219 Eden Landing Road, 94545, Hay word, California aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 354-357 0724-8741 14:3<354 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer