caa a22 4500 477126979 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012081501464 doi (NATIONALLICENCE)springer-10.1023/A:1012081501464 Application of Microdialysis in Pharmacokinetic Studies [Elektronische Daten] [William Elmquist, Ronald Sawchuk] The objective of this review is to survey the recent literature regarding the various applications of microdialysis in pharmacokinetics. Microdialysis is a relatively new technique for sampling tissue extracellular fluid that is gaining popularity in pharmacokinetic and pharmacodynamic studies, both in experimental animals and humans. The first part of this review discusses various aspects of the technique with regard to its use in pharmacokinetic studies, such as: quantitation of the microdialysis probe relative recovery, interfacing the sampling technique with analytical instrumentation, and consideration of repeated procedures using the microdialysis probe. The remainder of the review is devoted to a survey of the recent literature concerning pharmacokinetic studies that apply the microdialysis sampling technique. While the majority of the pharmacokinetic studies that have utilized microdialysis have been done in the central nervous system, a growing number of applications are being found in a variety of peripheral tissue types, e.g. skin, muscle, adipose, eye, lung, liver, and blood, and these are considered as well. Given the rising interest in this technique, and the ongoing attempts to adapt it to pharmacokinetic studies, it is clear that microdialysis sampling will have an important place in studying drug disposition and metabolism. Plenum Publishing Corporation, 1997 microdialysis sampling nationallicence pharmacokinetics nationallicence drug distribution nationallicence probe recovery nationallicence blood-brain barrier nationallicence extracellular fluid nationallicence Elmquist William Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 68198, Omaha, Nebraska aut Sawchuk Ronald Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 55455, Minneapolis, Minnesota aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 267-288 0724-8741 14:3<267 1997 14 11095 https://doi.org/10.1023/A:1012081501464 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012081501464 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elmquist William Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 68198, Omaha, Nebraska aut NATIONALLICENCE 700 1- Sawchuk Ronald Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 55455, Minneapolis, Minnesota aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 267-288 0724-8741 14:3<267 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer