caa a22 4500 477126995 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1012010407824 doi (NATIONALLICENCE)springer-10.1023/A:1012010407824 Antifungal Activity of a New Triterpenoid Glycoside from Pithecellobium racemosum (M.) [Elektronische Daten] [Ikhlas Khan, Alice Clark, James McChesney] Purpose. In a continuation of our search for novel antifungal compounds from higher plants, the standard extract of the bark of Pithecellobium racemosum was found to have good activity against important AIDS-related opportunistic yeasts. Methods. The extract was subjected to bioguided fractionation using silica gel column chromatography which led to purification of triterpene glycosides. The structures of these compounds were determined by a combination of spectroscopic (IR, NMR, HRMS) and chemical methods. Results. Compound 1 is a new glycoside, 3-O[α-L-arabinopyranosyl (1 -2)][α-L arabinopyranosyl (1 -6)]2-acetoamido-2-deoxy-β-D-gluco-pyranosyl oleanolic acid and Compound 2 was identified as the known compound 3-O-[α-L-arabinopyranosyl (l-2)]α-L-arabinopyranosyl (1-6)] 2-acetamido-2-deoxy-β-D-glucopyranosyl echinocystic acid. Conclusions. Compound 1 is a new glycoside, 3-O-[α-L-arabinopyranosyl (1-2)]α-L-arabinopyranosyl (l-6)]-2-acetoamido-2-deoxy-β-D-glucopyranosyl oleanolic acid and exhibits moderate antifungal activity against T. mentogrophytes, C. albicans and S. cerevisiae with MIC values of 6.25, 12.5 and 12.5 μg/ml respectively. Plenum Publishing Corporation, 1997 Pithecellobium racemosum nationallicence antifungal nationallicence triterpene glycoside nationallicence oleanolic acid nationallicence Carbon-13 NMR nationallicence Khan Ikhlas National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut Clark Alice National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut McChesney James National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 358-361 0724-8741 14:3<358 1997 14 11095 https://doi.org/10.1023/A:1012010407824 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012010407824 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khan Ikhlas National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut NATIONALLICENCE 700 1- Clark Alice National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut NATIONALLICENCE 700 1- McChesney James National Center for Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/3(1997-03-01), 358-361 0724-8741 14:3<358 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer