caa a22 4500 477127002 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19971001xx s 000 0 eng 10.1023/A:1012124806316 doi (NATIONALLICENCE)springer-10.1023/A:1012124806316 A New Ternary Polymeric Matrix System for Controlled Drug Delivery of Highly Soluble Drugs: I. Diltiazem Hydrochloride [Elektronische Daten] [Hyunjo Kim, Reza Fassihi] Purpose. The purpose of this study was to develop a new ternary polymeric matrix system that is easy to manufacture and that delivers a highly soluble drug over long periods of time. Methods. Pectin, hydroxypropylmethylcellulose (HPMC), and diltiazem HC1 granulated with gelatin at optimized ratios were blended at different loading doses and directly compressed. Swelling behavior, dissolution profiles and the effect of hydrodynamic stress on release kinetics were evaluated. Results. Diltiazem release kinetics from the ternary polymeric system was dependent on the different swelling behavior of the polymers and varied with the drug loading dose and hydrodynamic conditions. Drug release followed either non-Fickian or Case II transport kinetics. The relative influence of diffusion and relaxational/dissolution effects on release profiles for different drug loadings was calculated by a nonlinear regression approach. Photographs taken during swelling show that the anisotropic nature of the gel structure, drug loading dose, swelling capacity of polymers used, and the design of delivery system all play important roles in controlling the drug release and dissolution/ erosion processes. Conclusions. Zero-order delivery of diltiazem HC1 from a simple tablet matrix was achieved. The ternary polymeric system developed in this study is suitable for controlled release of highly soluble drugs. It offers a number of advantages over existing systems, including ease of manufacturing and of release modulation, as well as reproducibility of release profiles under well defined hydrodynamic conditions. Our delivery system has the potential to fully release its drug content in a controlled manner over a long time period and to dissolve completely. Plenum Publishing Corporation, 1997 ternary polymeric system nationallicence highly soluble drugs nationallicence controlled drug delivery nationallicence pectin: HPMC nationallicence gelatin system nationallicence simple hydrophilic matrix nationallicence diltiazem hydrochloride nationallicence Kim Hyunjo Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N. Broad St., 19140, Philadelphia, Pennsylvania aut Fassihi Reza Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N. Broad St., 19140, Philadelphia, Pennsylvania aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1415-1421 0724-8741 14:10<1415 1997 14 11095 https://doi.org/10.1023/A:1012124806316 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012124806316 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Hyunjo Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N. Broad St., 19140, Philadelphia, Pennsylvania aut NATIONALLICENCE 700 1- Fassihi Reza Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 N. Broad St., 19140, Philadelphia, Pennsylvania aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1415-1421 0724-8741 14:10<1415 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer