caa a22 4500 477127037 CHVBK 20180405111652.0 cr unu---uuuuu 170330e19971001xx s 000 0 eng 10.1023/A:1012185124972 doi (NATIONALLICENCE)springer-10.1023/A:1012185124972 Biomimetic Metabolism of Artelinic Acid by Chemical Cytochrome P-450 Model Systems [Elektronische Daten] [Olutosin Idowu, Ai Lin, James Grace, James Peggins] Purpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid. Methods. Artelinic acid was reacted with different organic complexes of iron(II). The reaction products were isolated and characterized by NMR and thermospray mass spectroscopy. Results. Five compounds which are putative metabolites of artelinic acid were isolated from these reactions and unambiguously identified, while the identity of two other compounds await final confirmation. Conclusions. Standards of possible metabolites of artelinic acid can be produced by the reaction of the compound with ferrous complexes that may simulate cytochrome P-450 catalyzed metabolism of xenobiotics. This approach may provide a simple and versatile method for the formation of metabolites of artemisinin compounds which is more advantageous than previous approaches with fungal-based systems. Plenum Publishing Corporation, 1997 antimalarial nationallicence artelinic acid nationallicence metabolites nationallicence chemical simulation of metabolism nationallicence Idowu Olutosin Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut Lin Ai Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut Grace James Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut Peggins James Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1449-1454 0724-8741 14:10<1449 1997 14 11095 https://doi.org/10.1023/A:1012185124972 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012185124972 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Idowu Olutosin Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut NATIONALLICENCE 700 1- Lin Ai Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut NATIONALLICENCE 700 1- Grace James Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut NATIONALLICENCE 700 1- Peggins James Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 20307-5100, Washington, D.C aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1449-1454 0724-8741 14:10<1449 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer