caa a22 4500 477127207 CHVBK 20180405111653.0 cr unu---uuuuu 170330e19971001xx s 000 0 eng 10.1023/A:1012197427698 doi (NATIONALLICENCE)springer-10.1023/A:1012197427698 Relationship Between Size of Injected Microspheres and Ultrasound Imaging of Heart by PLSR [Elektronische Daten] [K. Dyrstad, P. Sontum] Purpose. To investigate the enhancement in ultrasound signal (US) in heart, for diagnostic purposes, as a function of size and number of injected air-filled microspheres by multivariate statistical methods. Methods. The US enhancement in left ventricle was measured after injection of 31 suspensions of air-filled albumin microspheres divided on and injected in six dogs. The relationship between the size of microspheres between 1−38 μm and the US enhancement was explored by Pearson's product moment correlation analysis, ordinary least-squares regression, principal component regression (PCR) and partial least-squares regression (PLS). Results. Relative advanced algorithms such as PCR and PLS were required to achieve accurate in vivo/in vitro correlation. The most effective microsphere sizes contributing to US enhancement in left ventricle in dogs were estimated to be in the 7−15 μm range. Conclusions. In general, the effective in vivo sizes are dependent on the type of formulation due to the surprisingly large activein vivo sizes found for the tested concept. PCR and PLS are suitable methods forin vivo/in vitro correlation, especially for covariated and noisy data. Plenum Publishing Corporation, 1997 ultrasound imaging nationallicence heart nationallicence microspheres nationallicence multivariate analysis nationallicence Dyrstad K. Pharmaceutical Sciences, Research and Development Section, Nycomed Imaging AS, P.O. Box 4220 Torshov, N-0401, Oslo, Norway aut Sontum P. Analytical Sciences, Research and Development Section, Nycomed Imaging AS, P.O. Box 4220 Torshov, N-0401, Oslo, Norway aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1485-1489 0724-8741 14:10<1485 1997 14 11095 https://doi.org/10.1023/A:1012197427698 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012197427698 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dyrstad K. Pharmaceutical Sciences, Research and Development Section, Nycomed Imaging AS, P.O. Box 4220 Torshov, N-0401, Oslo, Norway aut NATIONALLICENCE 700 1- Sontum P. Analytical Sciences, Research and Development Section, Nycomed Imaging AS, P.O. Box 4220 Torshov, N-0401, Oslo, Norway aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/10(1997-10-01), 1485-1489 0724-8741 14:10<1485 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer